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SEC22B

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins
Full Name
SEC22 vesicle trafficking protein homolog B (S. cerevisiae)
Function
SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
Biological Process
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusion with Golgi apparatusManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus, cis-Golgi network membrane
Golgi apparatus, trans-Golgi network membrane
Melanosome
Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
Topology
Cytoplasmic: 2-194
Helical: 195-215
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Anti-SEC22B antibodies

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Mouse Anti-SEC22B Recombinant Antibody (1E1) (CBMAB-A7955-LY)

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Target: SEC22B
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human, Rat
Clone: 1E1
Application*: WB, E
Datasheet SDS

Mouse Anti-SEC22B Recombinant Antibody (5A10) (CBMAB-A7954-LY)

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Target: SEC22B
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human, Rat
Clone: 5A10
Application*: WB, E
Datasheet SDS

Mouse Anti-SEC22B Recombinant Antibody (CBXS-2751) (CBMAB-S5502-CQ)

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Target: SEC22B
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human, Rat
Clone: CBXS-2751
Application*: E, IF, WB
Datasheet SDS

Rabbit Anti-SEC22B Recombinant Antibody (CBXS-1317) (CBMAB-S4176-CQ)

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Target: SEC22B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1317
Application*: WB, IP, P, F, IF
Datasheet SDS

Mouse Anti-SEC22B (AA 1-111) Recombinant Antibody (CBXS-0179) (CBMAB-S3165-CQ)

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Target: SEC22B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-0179
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-SEC22B Recombinant Antibody (CBXS-5130) (CBMAB-S2348-CQ)

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Target: SEC22B
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: CBXS-5130
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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