SEC22B

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins

SEC22 vesicle trafficking protein homolog B (S. cerevisiae)

SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.

Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusion with Golgi apparatusManual Assertion Based On ExperimentIBA:GO_Central

Endoplasmic reticulum membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus, cis-Golgi network membrane
Golgi apparatus, trans-Golgi network membrane
Melanosome
Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).

Cytoplasmic: 2-194
Helical: 195-215