SLC32A1

The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II.

Full Name

Solute Carrier Family 32 Member 1

Function

Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity).
May also transport beta-alanine (By similarity).
Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity).

Biological Process

Biological Process agingIEA:Ensembl
Biological Process amino acid transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process beta-alanine transportISS:UniProtKB
Biological Process gamma-aminobutyric acid importISS:UniProtKB
Biological Process gamma-aminobutyric acid transportISS:UniProtKB
Biological Process glycine transportISS:UniProtKB
Biological Process hippocampus developmentIEA:Ensembl
Biological Process ion transportTAS:Reactome
Biological Process neurotransmitter loading into synaptic vesicleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neurotransmitter secretionTAS:Reactome

Cellular Location

Cytoplasmic vesicle membrane
Presynapse
Presents in glycine-, GABA- or GABA- and glycine-containing boutons.

Topology

Cytoplasmic: 1-132
Helical: 133-153
Lumenal: 154-204
Helical: 205-225
Cytoplasmic: 226-265
Helical: 266-286
Lumenal: 287-305
Helical: 306-326
Cytoplasmic: 327-341
Helical: 342-362
Lumenal: 363-383
Helical: 384-404
Cytoplasmic: 405-438
Helical: 439-459
Lumenal: 460-461
Helical: 462-482
Cytoplasmic: 483-489
Helical: 490-510
Lumenal: 490-510