SLC47A1

This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]

Full Name

Solute Carrier Family 47 Member 1

Function

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.

Biological Process

Biological Process amino acid import across plasma membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process L-alpha-amino acid transmembrane transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process L-arginine import across plasma membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process organic cation transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transmembrane transportTAS:Reactome
Biological Process xenobiotic detoxification by transmembrane export across the plasma membraneIEA:InterPro
Biological Process xenobiotic transportManual Assertion Based On ExperimentIMP:ARUK-UCL

Cellular Location

Cell membrane
Predominantly localized at the plasma membrane but also found in intracellular organelles.