TEX264

TEX264 (Testis Expressed 264) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+.

Full Name

TEX264 Gene(Protein Coding) Testis Expressed 264

Function

Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).
The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537).
Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537).
Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270).

Biological Process

Biological Process protein-DNA covalent cross-linking repairSource:UniProtKB1 Publication
Biological Process reticulophagySource:MGI1 Publication

Topology

Lumenal: 1-6
Helical: 7-31
Cytoplasmic: 32-313