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Mouse Anti-TEX264 Recombinant Antibody (CBYJT-2607) (CBMAB-T1777-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TEX264 (Testis Expressed 264). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TEX264 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2607
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
TEX264 (AAH08742, aa1-313) full-length recombinant protein with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-313

Target

Full Name
TEX264 Gene(Protein Coding) Testis Expressed 264
Introduction
TEX264 (Testis Expressed 264) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+.
Entrez Gene ID
51368
UniProt ID
Q9Y6I9
Alternative Names
Testis Expressed 264; Testis Expressed Gene 264; ZSIG11; Testis-Expressed Sequence 264 Protein; Putative Secreted Protein Zsig11; Testis Expressed Sequence 264; Testis-Expressed Protein 264
Function
Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).
The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537).
Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537).
Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270).
Biological Process
Biological Process protein-DNA covalent cross-linking repairSource:UniProtKB1 Publication
Biological Process reticulophagySource:MGI1 Publication
Topology
Lumenal: 1-6
Helical: 7-31
Cytoplasmic: 32-313
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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