Mouse Anti-TEX264 Recombinant Antibody (CBYJT-2607) (CBMAB-T1777-YJ)

Name: Mouse Anti-TEX264 Recombinant Antibody (CBYJT-2607)
SKU: CBMAB-T1777-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-2607

Application

ELISA, WB

Immunogen

TEX264 (AAH08742, aa1-313) full-length recombinant protein with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-313

More Infomation

Target

Full Name

TEX264 Gene(Protein Coding) Testis Expressed 264

Introduction

TEX264 (Testis Expressed 264) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+.

Entrez Gene ID

51368

UniProt ID

Q9Y6I9

Alternative Names

Testis Expressed 264; Testis Expressed Gene 264; ZSIG11; Testis-Expressed Sequence 264 Protein; Putative Secreted Protein Zsig11; Testis Expressed Sequence 264; Testis-Expressed Protein 264

Function

Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).
The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537).
Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537).
Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270).

Biological Process

Biological Process protein-DNA covalent cross-linking repairSource:UniProtKB1 Publication
Biological Process reticulophagySource:MGI1 Publication

Topology

Lumenal: 1-6
Helical: 7-31
Cytoplasmic: 32-313

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TEX264 Matched Antibody Pair (1196) (CAT#: APMAB-1196LY)

Related Products

Mouse Anti-TEX264 Recombinant Antibody (CBYJT-2606) (CAT#: CBMAB-T1776-YJ)

TEX264 Matched Antibody Pair (1196) (CAT#: APMAB-1196LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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