THRA

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

THRA Gene(Protein Coding) Thyroid Hormone Receptor, Alpha

Isoform Alpha-1
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Isoform Alpha-2
Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.

Biological Process cartilage condensationSource:Ensembl
Biological Process cell differentiationSource:GO_Central1 Publication
Biological Process erythrocyte differentiationSource:Ensembl
Biological Process female courtship behaviorSource:Ensembl
Biological Process hormone-mediated signaling pathwaySource:BHF-UCL1 Publication
Biological Process learning or memorySource:Ensembl
Biological Process mRNA transcription by RNA polymerase IISource:ComplexPortal
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription initiationSource:UniProtKB1 Publication
Biological Process negative regulation of RNA polymerase II transcription preinitiation complex assemblySource:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Biological Process ossificationSource:Ensembl
Biological Process positive regulation of cold-induced thermogenesisSource:YuBioLabBy Similarity
Biological Process positive regulation of female receptivitySource:Ensembl
Biological Process positive regulation of thyroid hormone mediated signaling pathwaySource:ComplexPortal
Biological Process positive regulation of transcription by RNA polymerase IISource:ComplexPortal1 Publication
Biological Process regulation of heart contractionSource:Ensembl
Biological Process regulation of lipid catabolic processSource:Ensembl
Biological Process regulation of myeloid cell apoptotic processSource:Ensembl
Biological Process regulation of thyroid hormone mediated signaling pathwaySource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:BHF-UCL1 Publication
Biological Process response to coldSource:Ensembl
Biological Process thyroid gland developmentSource:Ensembl
Biological Process thyroid hormone mediated signaling pathwaySource:GO_Central1 Publication
Biological Process transcription by RNA polymerase IISource:UniProtKB2 Publications
Biological Process type I pneumocyte differentiationSource:Ensembl

Nucleus
Isoform Alpha-2
Cytoplasm
Nucleus
When overexpressed found in the cytoplasm where it colocalizes with TACC1.

Hypothyroidism, congenital, non-goitrous, 6 (CHNG6):
A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.