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TRIM46

TRIM46 (Tripartite Motif Containing 46) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. An important paralog of TRIM46 is TRIM36.

Full Name

tripartite motif-containing 46

Function

Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.

Biological Process

Biological Process anterograde synaptic vesicle transport Source:GO_Central1 Publication
Biological Process axonogenesis Source:GO_Central1 Publication
Biological Process microtubule bundle formation Source:GO_Central1 Publication
Biological Process negative regulation of axon extension Source:ARUK-UCL
Biological Process neuron migration Source:GO_Central1 Publication
Biological Process positive regulation of anterograde dense core granule transport Source:ARUK-UCL
Biological Process protein localization to axon Source:Ensembl
Biological Process regulation of protein localization Source:ARUK-UCL

Cellular Location

Cell projection, axon
Cytoplasm, cytoskeleton
Microtubule-associated. Localizes to the proximal part of the axon.

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Anti-TRIM46 antibodies

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Mouse Anti-TRIM46 Recombinant Antibody (3G11) (CBMAB-A9520-LY)

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Target: TRIM46

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3G11

Application*: IF, E

Rat Trim46 ELISA Kit (V2LY-0626-LY2776)

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Target: Trim46

Sensitivity: 0.0098 ng/mL

Detection Range: 0.02-6 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Rat

Assay Type: Sandwich

Reactivity: Rat

Mouse Anti-TRIM46 Recombinant Antibody (CBYJT-4794) (CBMAB-T4335-YJ)

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Target: TRIM46

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-4794

Application*: SE, IF, E

Mouse Anti-TRIM46 Recombinant Antibody (CBYJT-4793) (CBMAB-T4334-YJ)

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Target: TRIM46

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-4793

Application*: E, IC, IF

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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