TRIM46

TRIM46 (Tripartite Motif Containing 46) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. An important paralog of TRIM46 is TRIM36.

Full Name

tripartite motif-containing 46

Function

Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.

Biological Process

Biological Process anterograde synaptic vesicle transport Source:GO_Central1 Publication
Biological Process axonogenesis Source:GO_Central1 Publication
Biological Process microtubule bundle formation Source:GO_Central1 Publication
Biological Process negative regulation of axon extension Source:ARUK-UCL
Biological Process neuron migration Source:GO_Central1 Publication
Biological Process positive regulation of anterograde dense core granule transport Source:ARUK-UCL
Biological Process protein localization to axon Source:Ensembl
Biological Process regulation of protein localization Source:ARUK-UCL

Cellular Location

Cell projection, axon
Cytoplasm, cytoskeleton
Microtubule-associated. Localizes to the proximal part of the axon.