UBA1

The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq]
Full Name
UBA1
Function
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181, PubMed:33108101).
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181).
Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).
Biological Process
Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process protein modification by small protein conjugation Source:GO_Central1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Mitochondrion
Nucleus
Isoform 1
Nucleus
Isoform 2
Cytoplasm
Involvement in disease
Spinal muscular atrophy X-linked 2 (SMAX2):
A lethal infantile form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. Clinical features include hypotonia, areflexia, and multiple congenital contractures.
VEXAS syndrome (VEXAS):
A sporadic, often fatal, treatment-refractory inflammatory syndrome that develops in late adulthood. Clinical features include fevers, cytopenias, characteristic vacuoles in myeloid and erythroid precursor cells, dysplastic bone marrow, neutrophilic cutaneous and pulmonary inflammation, chondritis, and vasculitis. The disease affects only males and is associated with de novo somatic mutations.
PTM
ISGylated.
View more

Anti-UBA1 antibodies

+ Filters
Loading...

Mouse Anti-UBA1 Recombinant Antibody (2B6) (CBMAB-A9693-LY)

Go to compareCompare
Target: UBA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B6
Application*: WB, E
Datasheet SDS

Mouse Anti-UBA1 Recombinant Antibody (CBFYU-021) (CBMAB-U0021-FY)

Go to compareCompare
Target: UBA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYU-021
Application*: IH, IP, WB
Datasheet SDS

Mouse Anti-UBA1 Recombinant Antibody (CBFYU-020) (CBMAB-U0020-FY)

Go to compareCompare
Target: UBA1
Host: Mouse
Specificity: Human
Clone: CBFYU-020
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-UBA1 Recombinant Antibody (CBFYU-019) (CBMAB-U0019-FY)

Go to compareCompare
Target: UBA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-019
Application*: IH, IP, WB
Datasheet SDS

Mouse Anti-UBA1 Recombinant Antibody (CBFYU-018) (CBMAB-U0018-FY)

Go to compareCompare
Target: UBA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYU-018
Application*: WB, IH, IP
Datasheet SDS

Mouse Anti-UBA1 Recombinant Antibody (CBFYU-017) (CBMAB-U0017-FY)

Go to compareCompare
Target: UBA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYU-017
Application*: E, WB
Datasheet SDS

Mouse Anti-UBA1 Antibody (12BA10) (CBMAB-1718CQ)

Go to compareCompare
Target: UBA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12BA10
Application*: E, WB
Datasheet SDS

Mouse Anti-UBA1 Antibody (12BA9) (CBMAB-1717CQ)

Go to compareCompare
Target: UBA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12BA9
Application*: E, WB
Datasheet SDS

Mouse Anti-UBA1 Antibody (12BA8) (CBMAB-1716CQ)

Go to compareCompare
Target: UBA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12BA8
Application*: E, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry
Happy Holidays
Happy Holidays close ad