USP46

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).

Full Name

Ubiquitin Specific Peptidase 46

Function

Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity).
Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029).
Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014).

Biological Process

Biological Process adult feeding behavior Source:Ensembl
Biological Process behavioral fear response Source:Ensembl
Biological Process behavioral response to ethanol Source:Ensembl
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of synaptic transmission, GABAergic Source:UniProtKB
Biological Process righting reflex Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

cytosol
nucleus