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USP46

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).

Full Name

Ubiquitin Specific Peptidase 46

Function

Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity).
Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029).
Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014).

Biological Process

Biological Process adult feeding behavior Source:Ensembl
Biological Process behavioral fear response Source:Ensembl
Biological Process behavioral response to ethanol Source:Ensembl
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of synaptic transmission, GABAergic Source:UniProtKB
Biological Process righting reflex Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

cytosol
nucleus

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Anti-USP46 antibodies

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Mouse Anti-USP46 Recombinant Antibody (CBXU-165) (CBMAB-U0233-CQ)

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Target: USP46

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXU-165

Application*: WB, IC

Mouse Anti-USP46 Recombinant Antibody (CBXU-164) (CBMAB-U0232-CQ)

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Target: USP46

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXU-164

Application*: WB

Human, Mouse Recombinant USP46 protein, SUMO Tag (V2LY-0526-LY7711)

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Target: USP46

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 1-366

Tag: SUMO Tag

Human, Mouse Recombinant USP46 protein (V2LY-0526-LY7710)

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Target: USP46

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 1-366

Human Recombinant USP46 protein, His Tag (V2LY-0526-LY7570)

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Target: USP46

Expressed Host: E. coli

Sequence: Amino Acid: Full Length

Tag: His Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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