USP46

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).
Full Name
Ubiquitin Specific Peptidase 46
Function
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity).
Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029).
Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014).
Biological Process
Biological Process adult feeding behavior Source:Ensembl
Biological Process behavioral fear response Source:Ensembl
Biological Process behavioral response to ethanol Source:Ensembl
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of synaptic transmission, GABAergic Source:UniProtKB
Biological Process righting reflex Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
cytosol
nucleus
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Anti-USP46 antibodies

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Mouse Anti-USP46 Recombinant Antibody (CBXU-165) (CBMAB-U0233-CQ)

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Target: USP46
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXU-165
Application*: WB, IC
Mouse Anti-USP46 Recombinant Antibody (CBXU-165)
Datasheet SDS

Mouse Anti-USP46 Recombinant Antibody (CBXU-164) (CBMAB-U0232-CQ)

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Target: USP46
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXU-164
Application*: WB
Mouse Anti-USP46 Recombinant Antibody (CBXU-164)
Datasheet SDS

Human, Mouse Recombinant USP46 protein, SUMO Tag (V2LY-0526-LY7711)

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Target: USP46
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-366
Tag: SUMO Tag
Human, Mouse Recombinant USP46 protein, SUMO Tag
Datasheet SDS

Human, Mouse Recombinant USP46 protein (V2LY-0526-LY7710)

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Target: USP46
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-366
Human, Mouse Recombinant USP46 protein
Datasheet SDS

Human Recombinant USP46 protein, His Tag (V2LY-0526-LY7570)

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Target: USP46
Expressed Host: E. coli
Sequence: Amino Acid: Full Length
Tag: His Tag
Human Recombinant USP46 protein, His Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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