ZDHHC7

Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).

Full Name

zinc finger DHHC-type containing 7

Function

Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:22031296, PubMed:27380321, PubMed:28196865).
Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity).
Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296).
Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095).
Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane (PubMed:25301068).
In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation (PubMed:27380321).
Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (PubMed:28196865).
Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity).
In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity).
Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity).
Could also palmitoylate NCDN (By similarity).
May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).

Biological Process

Biological Process glucose import in response to insulin stimulus Source:UniProtKB
Biological Process negative regulation of catabolic process Source:UniProtKB1 Publication
Biological Process peptidyl-L-cysteine S-palmitoylation Source:UniProtKB1 Publication
Biological Process polarized epithelial cell differentiation Source:UniProtKB1 Publication
Biological Process protein palmitoylation Source:UniProtKB1 Publication
Biological Process protein targeting to membrane Source:GO_Central1 Publication
Biological Process regulation of Fas signaling pathway Source:UniProtKB1 Publication
Biological Process regulation of G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process regulation of protein localization to cell-cell junction Source:UniProtKB1 Publication
Biological Process regulation of protein localization to plasma membrane Source:UniProtKB1 Publication

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-50
Helical: 51-71
Lumenal: 72-75
Helical: 76-96
Cytoplasmic: 97-173
Helical: 174-194
Lumenal: 195-217
Helical: 218-238
Cytoplasmic: 239-308

PTM

Autopalmitoylated.