ZNF268

Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.

Full Name

zinc finger protein 268

Function

Isoform 1
Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.
Isoform 2
Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.

Biological Process

Biological Process cell differentiation Source:UniProtKB-KW
Biological Process cellular response to tumor necrosis factor Source:UniProtKB
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of cell population proliferation Source:UniProtKB2 Publications
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cell differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of NIK/NF-kappaB signaling Source:UniProtKB
Biological Process positive regulation of protein catabolic process Source:UniProtKB
Biological Process positive regulation of protein homodimerization activity Source:UniProtKB
Biological Process positive regulation of protein phosphorylation Source:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of cell cycle Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process regulation of protein heterodimerization activity Source:UniProtKB
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication

Cellular Location

Isoform 1
Nucleus
Isoform 2
Nucleus
Cytoplasm