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Mouse Anti-ALDOA Recombinant Antibody (2E6) (CBMAB-A2310-YC)

Provided herein is a Mouse monoclonal antibody against Human Aldolase, Fructose-Bisphosphate A. The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all ALDOA antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
2E6
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ALDOA (AAH10660.1, 21 a.a. ~ 95 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aldolase, Fructose-Bisphosphate A
Introduction
ALDOA is a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate.
Entrez Gene ID
Human226
Mouse11674
UniProt ID
HumanP04075
MouseP05064
Alternative Names
Aldolase, Fructose-Bisphosphate A; Aldolase A, Fructose-Bisphosphate; Lung Cancer Antigen NY-LU-1; Muscle-Type Aldolase; EC 4.1.2.13; ALDA;
Function
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
Biological Process
Actin filament organization Source: BHF-UCL
ATP biosynthetic process Source: BHF-UCL
Binding of sperm to zona pellucida Source: CAFA
Canonical glycolysis Source: Reactome
Fructose 1,6-bisphosphate metabolic process Source: BHF-UCL
Fructose metabolic process Source: BHF-UCL
Gluconeogenesis Source: Reactome
Glycolytic process Source: BHF-UCL
Muscle cell cellular homeostasis Source: BHF-UCL
Neutrophil degranulation Source: Reactome
Platelet degranulation Source: Reactome
Protein homotetramerization Source: UniProtKB
Regulation of cell shape Source: BHF-UCL
Striated muscle contraction Source: BHF-UCL
Cellular Location
I band; M line. In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca2+.
Involvement in disease
Glycogen storage disease 12 (GSD12): A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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