ALDOA

This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]
Full Name
Aldolase, Fructose-Bisphosphate A
Function
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
Biological Process
Actin filament organization Source: BHF-UCL
ATP biosynthetic process Source: BHF-UCL
Binding of sperm to zona pellucida Source: CAFA
Canonical glycolysis Source: Reactome
Fructose 1,6-bisphosphate metabolic process Source: BHF-UCL
Fructose metabolic process Source: BHF-UCL
Gluconeogenesis Source: Reactome
Glycolytic process Source: BHF-UCL
Muscle cell cellular homeostasis Source: BHF-UCL
Neutrophil degranulation Source: Reactome
Platelet degranulation Source: Reactome
Protein homotetramerization Source: UniProtKB
Regulation of cell shape Source: BHF-UCL
Striated muscle contraction Source: BHF-UCL
Cellular Location
I band; M line. In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca2+.
Involvement in disease
Glycogen storage disease 12 (GSD12): A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis.
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Anti-ALDOA antibodies

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Mouse Anti-ALDOA Recombinant Antibody (A2) (CBMAB-A2316-YC)

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Target: ALDOA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: A2
Application*: WB, IP, IF, E, P
Datasheet SDS

Rabbit Anti-ALDOA Recombinant Antibody (D73H4) (CBMAB-A2314-YC)

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Target: ALDOA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: D73H4
Application*: WB
Datasheet SDS

Mouse Anti-ALDOA Recombinant Antibody (1F8) (CBMAB-A2317-YC)

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Target: ALDOA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 1F8
Application*: WB, IP, E
Datasheet SDS

Mouse Anti-ALDOA Recombinant Antibody (3F9) (CBMAB-A2313-YC)

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Target: ALDOA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F9
Application*: WB, FC, E, IC, IF
Datasheet SDS

Mouse Anti-ALDOA Recombinant Antibody (3D9-6F3) (CBMAB-A2312-YC)

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Target: ALDOA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3D9-6F3
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ALDOA Recombinant Antibody (3C12-6D11) (CBMAB-A2311-YC)

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Target: ALDOA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C12-6D11
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ALDOA Recombinant Antibody (2E6) (CBMAB-A2310-YC)

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Target: ALDOA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 2E6
Application*: E, WB
Datasheet SDS

Mouse Anti-ALDOA Recombinant Antibody (C10) (CBMAB-F1413-CQ)

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Target: ALDOA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: C10
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ALDOA Recombinant Antibody (CBT3349) (V2LY-0625-LY718)

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Target: ALDOA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBT3349
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-ALDOA Recombinant Antibody (CBT2236) (V2LY-0625-LY717)

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Target: ALDOA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2236
Application*: IC, F
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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