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Mouse Anti-ASH2L Recombinant Antibody (4G7) (CBMAB-A3776-YC)

Provided herein is a Mouse monoclonal antibody against Human ASH2 Like Histone Lysine Methyltransferase Complex Subunit. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all ASH2L antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4G7
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ASH2L (NP_004665. 1, 424-530 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 424-530

Target

Full Name
ASH2 Like Histone Lysine Methyltransferase Complex Subunit
Introduction
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates Lys-4 of histone H3, but not if the neighboring Lys-9 residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation a
Entrez Gene ID
9070
UniProt ID
Q9UBL3
Alternative Names
ASH2 Like Histone Lysine Methyltransferase Complex Subunit; ASH2-Like Protein; ASH2L1; Set1/Ash2 Histone Methyltransferase Complex Subunit ASH2; Ash2 (Absent, Small, Or Homeotic)-Like (Drosophila); Ash2 (Absent, Small, Or Homeotic)-Like; ASH2L2; ASH2; Bre
Function
Transcriptional regulator (PubMed:12670868).
Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338).
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245).
As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
May play a role in hematopoiesis (PubMed:12670868).
In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).
Biological Process
Beta-catenin-TCF complex assembly Source: Reactome
Cellular response to DNA damage stimulus Source: MGI
Hemopoiesis Source: UniProtKB
Histone H3-K4 methylation Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Regulation of megakaryocyte differentiation Source: Reactome
Response to estrogen Source: UniProtKB
Cellular Location
Nucleus
PTM
Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-296 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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