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Rabbit Anti-ASH2L Recombinant Antibody (CBAb021) (CBMAB-Ab021-LY)

The product is antibody recognizes ASH2L. The antibody CBAb021 immunoassay techniques such as: WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200.
See all ASH2L antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBAb021
Antibody Isotype
IgG
Application
WB, IHC, IF

Basic Information

Immunogen
A synthetic peptide corresponding to a sequence within amino acids 529-628 of human ASH2L.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
IF(ICC)1:50-1:200
IHC1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA, 50% glycerol, pH7.3
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ASH2 Like Histone Lysine Methyltransferase Complex Subunit
Entrez Gene ID
Human9070
Mouse23808
Rat290829
UniProt ID
HumanQ9UBL3
MouseQ91X20
RatD3ZTV7
Alternative Names
ASH2L; ASH2; ASH2L1; ASH2L2; Bre2; set1/Ash2 histone methyltransferase complex subunit ASH2
Function
Transcriptional regulator (PubMed:12670868).
Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338).
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245).
As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
May play a role in hematopoiesis (PubMed:12670868).
In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).
Biological Process
Beta-catenin-TCF complex assembly Source: Reactome
Cellular response to DNA damage stimulus Source: MGI
Hemopoiesis Source: UniProtKB
Histone H3-K4 methylation Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Regulation of megakaryocyte differentiation Source: Reactome
Response to estrogen Source: UniProtKB
Cellular Location
Nucleus
PTM
Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-296 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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