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ASH2L

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates Lys-4 of histone H3, but not if the neighboring Lys-9 residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at Lys-4 of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.
Full Name
ASH2 Like Histone Lysine Methyltransferase Complex Subunit
Function
Transcriptional regulator (PubMed:12670868).
Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338).
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245).
As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
May play a role in hematopoiesis (PubMed:12670868).
In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).
Biological Process
Beta-catenin-TCF complex assembly Source: Reactome
Cellular response to DNA damage stimulus Source: MGI
Hemopoiesis Source: UniProtKB
Histone H3-K4 methylation Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Regulation of megakaryocyte differentiation Source: Reactome
Response to estrogen Source: UniProtKB
Cellular Location
Nucleus
PTM
Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-296 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels.
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Anti-ASH2L antibodies

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Mouse Anti-ASH2L Recombinant Antibody (4G7) (CBMAB-A3776-YC)

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Target: ASH2L
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G7
Application*: E, WB
Datasheet SDS

Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640)

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Target: ASH2L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT2764
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-ASH2L Recombinant Antibody (CBT2107) (V2LY-0625-LY634)

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Target: ASH2L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2107
Application*: IH
Datasheet SDS

Rabbit Anti-ASH2L Recombinant Antibody (CBAb021) (CBMAB-Ab021-LY)

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Target: ASH2L
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb021
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-ASH2L Recombinant Antibody (CBYC-A825) (CBMAB-A3778-YC)

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Target: ASH2L
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A825
Application*: WB, IP, IF, FC
Datasheet SDS

Mouse Anti-ASH2L Recombinant Antibody (1B4) (CBMAB-A3775-YC)

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Target: ASH2L
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1B4
Application*: E, WB
Datasheet SDS

Rabbit Anti-ASH2L Recombinant Antibody (10E6) (CBMAB-A3774-YC)

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Target: ASH2L
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: 10E6
Application*: IF, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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