loading...

ASH2L

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates Lys-4 of histone H3, but not if the neighboring Lys-9 residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at Lys-4 of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.

Full Name

ASH2 Like Histone Lysine Methyltransferase Complex Subunit

Function

Transcriptional regulator (PubMed:12670868).
Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338).
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245).
As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
May play a role in hematopoiesis (PubMed:12670868).
In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).

Biological Process

Beta-catenin-TCF complex assembly Source: Reactome
Cellular response to DNA damage stimulus Source: MGI
Hemopoiesis Source: UniProtKB
Histone H3-K4 methylation Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Regulation of megakaryocyte differentiation Source: Reactome
Response to estrogen Source: UniProtKB

Cellular Location

Nucleus

PTM

Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-296 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels.

View more

Anti-ASH2L antibodies

Products List

+ Filters

Loading...

Mouse Anti-ASH2L Recombinant Antibody (4G7) (CBMAB-A3776-YC)

Compare

Target: ASH2L

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4G7

Application*: E, WB

Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640)

Compare

Target: ASH2L

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBT2764

Application*: WB, IH, F

Mouse Anti-ASH2L Recombinant Antibody (CBT2107) (V2LY-0625-LY634)

Compare

Target: ASH2L

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2107

Application*: IH

Rabbit Anti-ASH2L Recombinant Antibody (CBAb021) (CBMAB-Ab021-LY)

Compare

Target: ASH2L

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBAb021

Application*: WB, IH, IF

Mouse Anti-ASH2L Recombinant Antibody (CBYC-A825) (CBMAB-A3778-YC)

Compare

Target: ASH2L

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBYC-A825

Application*: WB, IP, IF, FC

Mouse Anti-ASH2L Recombinant Antibody (1B4) (CBMAB-A3775-YC)

Compare

Target: ASH2L

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1B4

Application*: E, WB

Rabbit Anti-ASH2L Recombinant Antibody (10E6) (CBMAB-A3774-YC)

Compare

Target: ASH2L

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey, Mouse, Rat

Clone: 10E6

Application*: IF, IP, WB

More Infomation

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

online inquiry

Online Inquiry