ASH2L

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates Lys-4 of histone H3, but not if the neighboring Lys-9 residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at Lys-4 of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.

ASH2 Like Histone Lysine Methyltransferase Complex Subunit

Transcriptional regulator (PubMed:12670868).
Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338).
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245).
As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
May play a role in hematopoiesis (PubMed:12670868).
In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).

Beta-catenin-TCF complex assembly Source: Reactome
Cellular response to DNA damage stimulus Source: MGI
Hemopoiesis Source: UniProtKB
Histone H3-K4 methylation Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Regulation of megakaryocyte differentiation Source: Reactome
Response to estrogen Source: UniProtKB

Nucleus

Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-296 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels.