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Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640)

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Tested Data
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in ELISA
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in ELISA
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in WB
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in WB
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in WB
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in WB
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in WB
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in WB
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in FC
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in FC
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in IHC
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in IHC
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in IHC
Mouse Anti-ASH2L Recombinant Antibody (CBT2764) (V2LY-0625-LY640) in IHC
Datasheet
SDS
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Basic Information

Host Animal
Mouse
Clone
CBT2764
Application
WB, IHC, FC
Immunogen
Purified recombinant fragment of human ASH2L (AA: 493-628) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
ASH2 Like Histone Lysine Methyltransferase Complex Subunit
Entrez Gene ID
9070
UniProt ID
Q9UBL3
Function
Transcriptional regulator (PubMed:12670868).
Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338).
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245).
As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
May play a role in hematopoiesis (PubMed:12670868).
In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).
Biological Process
Beta-catenin-TCF complex assembly Source: Reactome
Cellular response to DNA damage stimulus Source: MGI
Hemopoiesis Source: UniProtKB
Histone H3-K4 methylation Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Regulation of megakaryocyte differentiation Source: Reactome
Response to estrogen Source: UniProtKB
Cellular Location
Nucleus
PTM
Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-296 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels.

Lee, Y. T., Ayoub, A., Park, S. H., Sha, L., Xu, J., Mao, F., ... & Dou, Y. (2021). Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nature communications, 12(1), 1-13.

Wu, Y. J., Li, L. X., Liu, L., Zhao, S. S., Qiu, H. R., & Wang, H. (2020). ASH2L-Promoted HOXC8 Gene Expression Plays a Role in Mixed Lineage Leukemia-Rearranged Acute Leukemia. OncoTargets and therapy, 13, 381.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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