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Rat Anti-CCR10 Recombinant Antibody (248918) (CBMAB-C0724-LY)

This product is antibody recognizes CCR10. The antibody 248918 immunoassay techniques such as: FC, CyTOF.
See all CCR10 antibodies
Published Data
Fig.1 CCR10 depletion eliminates most CD4⁺ cells but not CD8⁺ T cells, as determined by flow cytometric analysis.
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Summary

Host Animal
Rat
Specificity
Mouse, Rat
Clone
248918
Antibody Isotype
IgG2b
Application
FC, CyTOF

Basic Information

Immunogen
C6 rat glioma cell line transfected with mouse CCR10, Met1-Asn362, Accession # NP_031747
Specificity
Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-C Motif Chemokine Receptor 10
Introduction
CCR10 (C-C Motif Chemokine Receptor 10) is a Protein Coding gene. Diseases associated with CCR10 include Mycosis Fungoides and Sezary's Disease. Among its related pathways are Akt Signaling and Allograft rejection. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity.
An important paralog of this gene is CXCR3.
Entrez Gene ID
Mouse12777
Rat363682
UniProt ID
MouseQ9JL21
RatD3ZJH1
Function
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
Biological Process
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-52
Helical: 53-68
Cytoplasmic: 69-78
Helical: 79-99
Extracellular: 100-114
Helical: 115-136
Cytoplasmic: 137-159
Helical: 160-179
Extracellular: 180-203
Helical: 204-225
Cytoplasmic: 226-247
Helical: 248-269
Extracellular: 270-290
Helical: 291-313
Cytoplasmic: 314-362
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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