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Rat Anti-CCR10 Recombinant Antibody (314305) (CBMAB-C0949-LY)

This product is antibody recognizes CCR10. The antibody 314305 immunoassay techniques such as: FC, CyTOF.
See all CCR10 antibodies
Published Data
Fig.1 Expression of CCR6, CXCR3, CCR4 and CCR10 by gated CD4+CD45RO+CD25-CD127+ Th cells from peripheral blood.
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Fig.2 Mouse functional E-selectin ligand-positive CCR10⁺CD4⁺ T cells was detected in control-treated mice.
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Summary

Host Animal
Rat
Specificity
Human
Clone
314305
Antibody Isotype
IgG2a
Application
FC, CyTOF

Basic Information

Immunogen
Y3 rat myeloid cell line transfected with human CCR10, Gln8-Asn362, Accession # P46092
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-C Motif Chemokine Receptor 10
Introduction
CCR10 (C-C Motif Chemokine Receptor 10) is a Protein Coding gene. Diseases associated with CCR10 include Mycosis Fungoides and Sezary's Disease. Among its related pathways are Akt Signaling and Allograft rejection. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity.
An important paralog of this gene is CXCR3.
Entrez Gene ID
2826
UniProt ID
P46092
Alternative Names
C-C Motif Chemokine Receptor 10; Chemokine (C-C Motif) Receptor 10; G-Protein Coupled Receptor 2; C-C CKR-10; CC-CKR-10; CCR-10;
Function
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
Biological Process
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-52
Helical: 53-68
Cytoplasmic: 69-78
Helical: 79-99
Extracellular: 100-114
Helical: 115-136
Cytoplasmic: 137-159
Helical: 160-179
Extracellular: 180-203
Helical: 204-225
Cytoplasmic: 226-247
Helical: 248-269
Extracellular: 270-290
Helical: 291-313
Cytoplasmic: 314-362
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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