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Mouse Anti-CCR10 Recombinant Antibody (CBYY-C1129) (CBMAB-C2566-YY)

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Published Data
CBMAB-C2566-YY-1
Mouse Anti-CCR10 Recombinant Antibody (CBYY-C1129) (CBMAB-C2566-YY) in WB
Western blotting analysis of CCR10 protein expression in hepatocytes isolated from HCC tumor specimens and matching paracancerous tissue specimens as well as normal liver specimens. ...View More
Wu, Q., Chen, J. X., Chen, Y., Cai, L. L., Wang, X. Z., Guo, W. H., & Zheng, J. F. (2018). The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation. Cell Death & Disease, 9(2), 232.
CBMAB-C2566-YY-2
Mouse Anti-CCR10 Recombinant Antibody (CBYY-C1129) (CBMAB-C2566-YY) in WB
Western blotting analysis of TNF and CCR10 protein expression in WT murine liver tissue after i.p. injection regimen of either CCl4 or physiological saline (vehicle). ...View More
Wu, Q., Chen, J. X., Chen, Y., Cai, L. L., Wang, X. Z., Guo, W. H., & Zheng, J. F. (2018). The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation. Cell Death & Disease, 9(2), 232.
Datasheet
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBYY-C1129
Application
WB, IP, IF, ELISA, IHC-P
Immunogen
Amino acids 141-290 mapping within an internal region of CKR-10 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
C-C Motif Chemokine Receptor 10
Entrez Gene ID
Mouse12777
Rat363682
UniProt ID
MouseQ9JL21
RatD3ZJH1
Alternative Names
C9orf164, CD100, COLL4, M-sema-G, SEMAJ, coll-4
Function
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
Biological Process
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-52
Helical: 53-68
Cytoplasmic: 69-78
Helical: 79-99
Extracellular: 100-114
Helical: 115-136
Cytoplasmic: 137-159
Helical: 160-179
Extracellular: 180-203
Helical: 204-225
Cytoplasmic: 226-247
Helical: 248-269
Extracellular: 270-290
Helical: 291-313
Cytoplasmic: 314-362

Lim, H. D., Lane, J. R., Canals, M., & Stone, M. J. (2021). Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10. International Journal of Molecular Sciences, 22(8), 4232.

Korbecki, J., Grochans, S., Gutowska, I., Barczak, K., & Baranowska-Bosiacka, I. (2020). CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands. International journal of molecular sciences, 21(20), 7619.

Kawano, Y., Kakoki, M., Inada, Y., Nishimura, N., Okuno, Y., Hata, H., & Matsuoka, M. (2017). Altered Expression of CCR10 Indicates Malignant Transformation of Bone Marrow Plasma Cells. Blood, 130(Supplement 1), 1782-1782.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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