Human Anti-CCR10 Recombinant Antibody (CBXC-0808) (CBMAB-C1922-CQ)

Name: Human Anti-CCR10 Recombinant Antibody (CBXC-0808)
SKU: CBMAB-C1922-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Human

Clone

CBXC-0808

Application

Immunogen

Human CCR10 transfected cells

Host Species

Human

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Buffer containing stabilizer

Preservative

0.05% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

C-C Motif Chemokine Receptor 10

Introduction

CCR10 (C-C Motif Chemokine Receptor 10) is a Protein Coding gene. Diseases associated with CCR10 include Mycosis Fungoides and Sezary's Disease. Among its related pathways are Akt Signaling and Allograft rejection. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CXCR3.

Entrez Gene ID

2826

UniProt ID

P46092

Alternative Names

C-C Motif Chemokine Receptor 10; Chemokine (C-C Motif) Receptor 10; G-Protein Coupled Receptor 2; C-C CKR-10; CC-CKR-10; CCR-10;

Function

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Biological Process

Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-52
Helical: 53-68
Cytoplasmic: 69-78
Helical: 79-99
Extracellular: 100-114
Helical: 115-136
Cytoplasmic: 137-159
Helical: 160-179
Extracellular: 180-203
Helical: 204-225
Cytoplasmic: 226-247
Helical: 248-269
Extracellular: 270-290
Helical: 291-313
Cytoplasmic: 314-362

Lim, H. D., Lane, J. R., Canals, M., & Stone, M. J. (2021). Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10. International Journal of Molecular Sciences, 22(8), 4232.

Korbecki, J., Grochans, S., Gutowska, I., Barczak, K., & Baranowska-Bosiacka, I. (2020). CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands. International journal of molecular sciences, 21(20), 7619.

Kawano, Y., Kakoki, M., Inada, Y., Nishimura, N., Okuno, Y., Hata, H., & Matsuoka, M. (2017). Altered Expression of CCR10 Indicates Malignant Transformation of Bone Marrow Plasma Cells. Blood, 130(Supplement 1), 1782-1782.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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