Mouse Anti-DKKL1 Recombinant Antibody (CBXS-2278) (CBMAB-S5040-CQ)

Name: Mouse Anti-DKKL1 Recombinant Antibody (CBXS-2278)
SKU: CBMAB-S5040-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-2278

Application

WB, IP, IF, ELISA

Specificity

Mouse

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

dickkopf-like 1

Introduction

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Entrez Gene ID

50722

UniProt ID

Q9QZL9

Alternative Names

AI414495; SGY; SGY-1; SGY1; Soggy; mSgy

Function

Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.

Biological Process

Anatomical structure morphogenesis Source: ProtInc
Negative regulation of canonical Wnt signaling pathway Source: GO_Central
Negative regulation of testosterone biosynthetic process Source: UniProtKB
Penetration of zona pellucida Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of fat cell differentiation Source: Ensembl

Cellular Location

Secreted; Acrosome. Localized specifically to the crescent shaped acrosome at the apex of the sperm head.

PTM

N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm.

Yan, Q. X., Ma, Y., Chen, R. Q., Zhou, X. Q., Qiao, J., Xian, Y. J., ... & Chen, C. R. (2018). Expression of DKKL1 in spermatozoa of men with asthenospermia. Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 38(3), 324-328.

Martin, G., Selcuklu, S. D., Schouest, K., Nembaware, V., McKeown, P. C., Seoighe, C., & Spillane, C. (2017). Allele-specific splicing effects on DKKL1 and ZNF419 transcripts in HeLa cells. Gene, 598, 107-112.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-DKKL1 Recombinant Antibody (CBXS-2278) (CAT#: V2LY-0425-LY410)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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