Rat Anti-DKKL1 Recombinant Antibody (CBXS-5633) (V2LY-0425-LY408)

Name: Rat Anti-DKKL1 Recombinant Antibody (CBXS-5633)
SKU: V2LY-0425-LY408
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBXS-5633

Application

Immunogen

Mouse myeloma cell line derived recombinant mouse DkkL1 (Leu21-Leu230).

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	0.5 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Trehalose & PBS

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

dickkopf-like 1

Entrez Gene ID

50722

UniProt ID

Q9QZL9

Function

Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.

Biological Process

Anatomical structure morphogenesis Source: ProtInc
Negative regulation of canonical Wnt signaling pathway Source: GO_Central
Negative regulation of testosterone biosynthetic process Source: UniProtKB
Penetration of zona pellucida Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of fat cell differentiation Source: Ensembl

Cellular Location

Secreted; Acrosome. Localized specifically to the crescent shaped acrosome at the apex of the sperm head.

PTM

N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm.

Yan, Q. X., Ma, Y., Chen, R. Q., Zhou, X. Q., Qiao, J., Xian, Y. J., ... & Chen, C. R. (2018). Expression of DKKL1 in spermatozoa of men with asthenospermia. Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 38(3), 324-328.

Martin, G., Selcuklu, S. D., Schouest, K., Nembaware, V., McKeown, P. C., Seoighe, C., & Spillane, C. (2017). Allele-specific splicing effects on DKKL1 and ZNF419 transcripts in HeLa cells. Gene, 598, 107-112.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Anti-DKKL1 Recombinant Antibody (CBXS-5633) (CAT#: CBMAB-S0510-CQ)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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