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Rat Anti-DKKL1 Recombinant Antibody (CBXS-5633) (CBMAB-S0510-CQ)

This product is a rat antibody that recognizes DKKL1. The antibody CBXS-5633 can be used for immunoassay techniques such as: WB.
See all DKKL1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXS-5633
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Mouse DKKL1
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
dickkopf-like 1
Introduction
The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Entrez Gene ID
50722
UniProt ID
Q9QZL9
Alternative Names
AI414495; SGY; SGY-1; SGY1; Soggy; mSgy
Function
Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Negative regulation of canonical Wnt signaling pathway Source: GO_Central
Negative regulation of testosterone biosynthetic process Source: UniProtKB
Penetration of zona pellucida Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of fat cell differentiation Source: Ensembl
Cellular Location
Secreted; Acrosome. Localized specifically to the crescent shaped acrosome at the apex of the sperm head.
PTM
N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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