DKKL1

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Full Name

dickkopf-like 1

Function

Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.

Biological Process

Anatomical structure morphogenesis Source: ProtInc
Negative regulation of canonical Wnt signaling pathway Source: GO_Central
Negative regulation of testosterone biosynthetic process Source: UniProtKB
Penetration of zona pellucida Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of fat cell differentiation Source: Ensembl

Cellular Location

Secreted; Acrosome. Localized specifically to the crescent shaped acrosome at the apex of the sperm head.

PTM

N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm.

Anti-DKKL1 antibodies

Mouse Anti-DKKL1 Recombinant Antibody (6G10) (CBMAB-D1004-YC)

Datasheet

SDS

Target: DKKL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6G10

Application*: WB

Rat Anti-DKKL1 Recombinant Antibody (CBXS-5633) (CBMAB-S0510-CQ)

Datasheet

SDS

Target: DKKL1

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBXS-5633

Application*: WB

Mouse Anti-DKKL1 Recombinant Antibody (CBXS-5832) (CBMAB-S0687-CQ)

Datasheet

SDS

Target: DKKL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5832

Application*: WB

Mouse Anti-DKKL1 Recombinant Antibody (CBXS-2278) (CBMAB-S5040-CQ)

Datasheet

SDS

Target: DKKL1

Host: Mouse

Specificity: Mouse

Clone: CBXS-2278

Application*: WB, IP, IF, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)