DKKL1

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Full Name
dickkopf-like 1
Function
Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Negative regulation of canonical Wnt signaling pathway Source: GO_Central
Negative regulation of testosterone biosynthetic process Source: UniProtKB
Penetration of zona pellucida Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of fat cell differentiation Source: Ensembl
Cellular Location
Secreted; Acrosome. Localized specifically to the crescent shaped acrosome at the apex of the sperm head.
PTM
N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm.
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Anti-DKKL1 antibodies

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Mouse Anti-DKKL1 Recombinant Antibody (CBXS-2278) (CBMAB-S5040-CQ)

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Target: DKKL1
Host: Mouse
Specificity: Mouse
Clone: CBXS-2278
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DKKL1 Recombinant Antibody (CBXS-5832) (CBMAB-S0687-CQ)

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Target: DKKL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5832
Application*: WB
Datasheet SDS

Rat Anti-DKKL1 Recombinant Antibody (CBXS-5633) (CBMAB-S0510-CQ)

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Target: DKKL1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXS-5633
Application*: WB
Datasheet SDS

Mouse Anti-DKKL1 Recombinant Antibody (6G10) (CBMAB-D1004-YC)

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Target: DKKL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G10
Application*: WB
Datasheet SDS

Human DKKL1 ELISA Kit (V2LY-0626-LY3652)

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Target: DKKL1
Sensitivity: 0.018 ng/mL
Detection Range: 0.05-15 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Dkkl1 ELISA Kit (V2LY-0626-LY1488)

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Target: Dkkl1
Sensitivity: 0.0095 ng/mL
Detection Range: 0.02-7 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Human Recombinant DKKL1 protein, hFc Tag (V2LY-0526-LY3585)

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Target: DKKL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 31-242
Tag: hFc Tag
Datasheet SDS

Mouse Anti-DKKL1 Recombinant Antibody (CBXS-2278) (V2LY-0425-LY410)

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Target: DKKL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBXS-2278
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DKKL1 Recombinant Antibody (CBXS-5832) (V2LY-0425-LY409)

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Target: DKKL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBXS-5832
Application*: WB, IP, IF, E
Datasheet SDS

Rat Anti-DKKL1 Recombinant Antibody (CBXS-5633) (V2LY-0425-LY408)

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Target: DKKL1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXS-5633
Application*: WB
Datasheet SDS

Mouse Anti-DKKL1 Recombinant Antibody (D1004) (V2LY-0425-LY407)

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Target: DKKL1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: D1004
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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