Mouse Anti-POSTN (AA 1-230) Recombinant Antibody (CBXO-0536) (CBMAB-O0643-CQ)

Name: Mouse Anti-POSTN (AA 1-230) Recombinant Antibody (CBXO-0536)
SKU: CBMAB-O0643-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXO-0536

Application

Immunogen

Recombinant human periostin (aa 1-230)

Specificity

Human

Antibody Isotype

IgM

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% Sodium Azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-230

More Infomation

Target

Full Name

Periostin

Introduction

This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms.

Entrez Gene ID

10631

UniProt ID

Q15063

Alternative Names

PN; OSF2; OSF-2; PDLPOSTN

Function

Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007).
Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).

Biological Process

Cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to vitamin KManual Assertion Based On ExperimentIDA:UniProtKB
Extracellular matrix organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of Notch signaling pathwayIEA:Ensembl
Tissue developmentIEA:Ensembl

Cellular Location

Golgi apparatus
Secreted
Secreted, extracellular space, extracellular matrix
Colocalizes with BMP1 in the Golgi.

PTM

Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding (PubMed:18450759).
According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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