AIM2

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]

Absent In Melanoma 2

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Activation of innate immune response Source: UniProtKB
Apoptotic process Source: UniProtKB-KW
Cellular response to drug Source: MGI
Cellular response to interferon-beta Source: GO_Central
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
NLRP3 inflammasome complex assembly Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity Source: UniProtKB
Positive regulation of defense response to virus by host Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Pyroptosis Source: UniProtKB
Pyroptosome complex assembly Source: GO_Central
Tumor necrosis factor-mediated signaling pathway Source: UniProtKB

Cytoplasm; Nucleus. Activated inflammasomes can aggregate in the cytosol as speck-like particles.