ANLN

ANLN is an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated w

Full Name

Anillin Actin Binding Protein

Function

Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636).

Biological Process

Actomyosin contractile ring assembly Source: GO_Central
Glomerular visceral epithelial cell migration Source: UniProtKB
Mitotic cytokinesis Source: MGI
Positive regulation of bleb assembly Source: UniProtKB
Regulation of exit from mitosis Source: ProtInc
Septin ring assembly Source: ProtInc
Septin ring organization Source: GO_Central

Cellular Location

Cytoskeleton; Nucleus; Cell cortex; Bleb. Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.

Involvement in disease

Focal segmental glomerulosclerosis 8 (FSGS8): A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.

PTM

Phosphorylated during mitosis.
Ubiquitinated, and this requires FZR1/CDH1.