APIP

APIP is an APAF1-interacting protein that acts as a negative regulator of ischemic/hypoxic injury.

APAF1 Interacting Protein

Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.

Apoptotic process Source: UniProtKB-KW
L-methionine salvage from methylthioadenosine Source: UniProtKB
L-methionine salvage from S-adenosylmethionine Source: UniProtKB-UniRule
Negative regulation of apoptotic process Source: UniProtKB
Protein homotetramerization Source: UniProtKB
Pyroptosis Source: UniProtKB
Regulation of ERK1 and ERK2 cascade Source: UniProtKB

Cytoplasm