ASF1A

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]
Full Name
Anti-Silencing Function 1A Histone Chaperone
Function
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
Biological Process
DNA repair Source: MGI
DNA replication-dependent nucleosome assembly Source: UniProtKB
DNA replication-independent nucleosome assembly Source: UniProtKB
Muscle cell differentiation Source: Ensembl
Negative regulation of chromatin silencing Source: UniProtKB
Nucleosome assembly Source: MGI
Osteoblast differentiation Source: Ensembl
Cellular Location
Nucleus
PTM
Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation.
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Anti-ASF1A antibodies

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Mouse Anti-ASF1A Antibody (2A5F8) (CBMAB-0134-YC)

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Target: ASF1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A5F8
Application*: E, WB, FC
Datasheet SDS

Mouse Anti-ASF1A Recombinant Antibody (CBT4630) (V2LY-0625-LY804)

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Target: ASF1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4630
Application*: F
Datasheet SDS

Rabbit Anti-ASF1A Recombinant Antibody (C6E10) (CBMAB-A3754-YC)

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Target: ASF1A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: C6E10
Application*: WB, IP, P, IF
Datasheet SDS

Mouse Anti-ASF1A Recombinant Antibody (8D7) (CBMAB-A3752-YC)

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Target: ASF1A
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Rat
Clone: 8D7
Application*: WB, IF
Datasheet SDS

Mouse Anti-ASF1A Recombinant Antibody (2G10) (CBMAB-A3751-YC)

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Target: ASF1A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G10
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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