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ASF1A

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]

Full Name

Anti-Silencing Function 1A Histone Chaperone

Function

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Biological Process

DNA repair Source: MGI
DNA replication-dependent nucleosome assembly Source: UniProtKB
DNA replication-independent nucleosome assembly Source: UniProtKB
Muscle cell differentiation Source: Ensembl
Negative regulation of chromatin silencing Source: UniProtKB
Nucleosome assembly Source: MGI
Osteoblast differentiation Source: Ensembl

Cellular Location

Nucleus

PTM

Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation.

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Anti-ASF1A antibodies

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Mouse Anti-ASF1A Antibody (2A5F8) (CBMAB-0134-YC)

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Target: ASF1A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2A5F8

Application*: E, WB, FC

Mouse Anti-ASF1A Recombinant Antibody (CBT4630) (V2LY-0625-LY804)

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Target: ASF1A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT4630

Application*: F

Rabbit Anti-ASF1A Recombinant Antibody (C6E10) (CBMAB-A3754-YC)

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Target: ASF1A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Monkey

Clone: C6E10

Application*: WB, IP, P, IF

Mouse Anti-ASF1A Recombinant Antibody (8D7) (CBMAB-A3752-YC)

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Target: ASF1A

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human, Rat

Clone: 8D7

Application*: WB, IF

Mouse Anti-ASF1A Recombinant Antibody (2G10) (CBMAB-A3751-YC)

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Target: ASF1A

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2G10

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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