BCAT1
This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. [provided by RefSeq]
Full Name
branched chain aminotransferase 1, cytosolic
Function
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Biological Process
Branched-chain amino acid biosynthetic process Source: ProtInc
Branched-chain amino acid catabolic process Source: Reactome
G1/S transition of mitotic cell cycle Source: ProtInc
Leucine biosynthetic process Source: GO_Central
Valine biosynthetic process Source: GO_Central
Branched-chain amino acid catabolic process Source: Reactome
G1/S transition of mitotic cell cycle Source: ProtInc
Leucine biosynthetic process Source: GO_Central
Valine biosynthetic process Source: GO_Central
Cellular Location
Cytoplasm
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Anti-BCAT1 antibodies
+ Filters
Target: BCAT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-0294
Application*: E, WB
Target: BCAT1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey, Cat
Clone: 3F5
Application*: WB, IH
Target: BCAT1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1F8
Application*: WB, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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