c-Reactive Protein (CRP) Canine

Full Name

Function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Biological Process

Acute-phase response Source: BHF-UCL
Complement activation, classical pathway Source: GO_Central
Defense response to Gram-positive bacterium Source: BHF-UCL
Inflammatory response Source: ProtInc
Innate immune response Source: GO_Central
Negative regulation by host of viral process Source: GO_Central
Negative regulation of lipid storage Source: BHF-UCL
Negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Negative regulation of mononuclear cell proliferation Source: CACAO
Opsonization Source: BHF-UCL
Positive regulation of gene expression Source: AgBase
Positive regulation of superoxide anion generation Source: AgBase
Regulation of interleukin-8 production Source: UniProtKB
Vasoconstriction Source: GO_Central

Cellular Location

Secreted