CACNA1C Antibodies

Structure of CACNA1C

The Cav1.2 protein encoded by the CACNA1C gene is a transmembrane channel protein with a molecular weight of approximately 250 kDa. This protein consists of four highly homologous domains (I-IV), and each domain contains six transmembrane helical fragments (S1-S6).

In each domain of this protein, the S4 helix acts as a voltage sensor, and its positively charged amino acid residues shift when the membrane potential changes, thereby activating the channel. The S5 and S6 helices and the P ring between them jointly form the central channel, in which the highly conserved glutamic acid residues form a calcium ion-selective filter, ensuring the specific permeability of calcium ions. The intracellular loop located at the junction of the III-IV domain is involved in the regulation of the channel inactivation process.

Fig. 1 CACNA1C Dysfunction and Disease: A Tale of Both Gain and Loss.¹

Key structural properties of CACNA1C:

• Quadruple transmembrane domain (I-IV), each containing 6 helical segments (S1-S6)
• S4 spiral section is rich in positively charged arginine
• The channel between S5 - S6 ring form ion selective filter (P - loop)
• The intracellular linking loop between domains III-IV regulates the rapid inactivation process

Functions of CACNA1C

The Cav1.2 channel encoded by the CACNA1C gene plays a core role in calcium signal transduction, and its functions cover multiple aspects such as electrophysiological regulation and gene expression regulation.

The activation of this channel is voltage-dependent, and its current-voltage relationship curve conforms to the typical "S" -shaped activation characteristics. Compared with the transient sodium channel, its inactivation process is slow and incomplete. This feature makes it particularly suitable for maintaining continuous calcium influx, thereby playing a dual role of long-term signal guidance and second messenger source in excitatory cells.

Applications of CACNA1C and CACNA1C Antibody in Literature

1. Chang, Xiaohan, and Yunxia Dong. "CACNA1C is a prognostic predictor for patients with ovarian cancer." Journal of Ovarian Research 14.1 (2021): 88. https://doi.org/10.1186/s13048-021-00830-z

The article indicates that in ovarian cancer, the expression of CACNA1C is significantly reduced and it is an independent risk factor for the overall survival of patients. This gene is closely related to microsatellite instability and immune regulation, and can be used as a potential prognostic predictor.

2. Loganathan, Srivaishnavi, et al. "Cacna1c deficiency in forebrain glutamatergic neurons alters behavior and hippocampal plasticity in female mice." Translational Psychiatry 14.1 (2024): 421. https://doi.org/10.1038/s41398-024-03140-2

This study focused on the CACNA1C gene and found that specific knockout of this gene in the brains of female mice would lead to behavioral abnormalities such as anxiety and cognitive impairment. These changes are related to the simplification of dendritic structure and alterations in synaptic function of hippocampal neurons, providing new evidence for understanding their pathogenic mechanism.

3. Datta, Dibyadeep, et al. "Key roles of CACNA1C/Cav1. 2 and CALB1/calbindin in prefrontal neurons altered in cognitive disorders." JAMA psychiatry 81.9 (2024): 870-881. https://doi.org/10.1001/jamapsychiatry.2024.1112

Research has found that key neurons in the prefrontal cortex of the brain highly express CACNA1C (Cav1.2 calcium channel). Both insufficient and excessive activity of this channel can damage memory-related neural discharges, which explains why its functional loss or acquired variation increases the risk of cognitive impairment.

4. Cipriano, Lorenzo, et al. "Expanding the phenotype of the CACNA1C-associated neurological disorders in children: systematic literature review and description of a novel mutation." Children 11.5 (2024): 541. https://doi.org/10.3390/children11050541

Research has found that mutations in the CACNA1C gene can lead to isolated phenotypes mainly characterized by neurological abnormalities (such as developmental delay and cognitive impairment). Even without cardiac symptoms, subtle abnormalities such as teeth and gums may occur, suggesting that the disease spectrum related to this gene is extensive and diverse in manifestation.

5. Zhu, Dongjian, et al. "CACNA1C (rs1006737) may be a susceptibility gene for schizophrenia: An updated meta‐analysis." Brain and behavior 9.6 (2019): e01292. https://doi.org/10.1002/brb3.1292

Research has found that through large-sample meta-analysis, the mutation at the rs1006737 locus of the CACNA1C gene has been confirmed as a significant risk factor for schizophrenia in the global population, especially with a clear association in the European population, supporting that this gene is a disease susceptibility gene.

Creative Biolabs: CACNA1C Antibodies for Research

Creative Biolabs specializes in the production of high-quality CACNA1C antibodies for research and industrial applications. Our portfolio includes monoclonal antibodies tailored for ELISA, Flow Cytometry, Western blot, immunohistochemistry, and other diagnostic methodologies.

• Custom CACNA1C Antibody Development: Tailor-made solutions to meet specific research requirements.
• Bulk Production: Large-scale antibody manufacturing for industry partners.
• Technical Support: Expert consultation for protocol optimization and troubleshooting.
• Aliquoting Services: Conveniently sized aliquots for long-term storage and consistent experimental outcomes.

For more details on our CACNA1C antibodies, custom preparations, or technical support, contact us at email.