CAMKK2

This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. The protein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling. [provided by RefSeq, Sep 2012]
Full Name
Calcium/Calmodulin Dependent Protein Kinase Kinase 2
Function
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals (By similarity).
Seems to be involved in hippocampal activation of CREB1 (By similarity).
May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Biological Process
Calcium-mediated signaling Source: UniProtKB
CAMKK-AMPK signaling cascade Source: ParkinsonsUK-UCL
Cellular response to reactive oxygen species Source: ParkinsonsUK-UCL
Chemical synaptic transmission Source: Reactome
MAPK cascade Source: UniProtKB
Positive regulation of autophagy of mitochondrion Source: ParkinsonsUK-UCL
Positive regulation of protein phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of protein kinase activity Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm; Neuron projection. Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction.
PTM
Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.
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Anti-CAMKK2 antibodies

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Rabbit Anti-CAMKK2 Recombinant Antibody (D8D4D) (CBMAB-CP0088-LY)

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Target: CAMKK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D8D4D
Application*: WB
Datasheet SDS

Mouse Anti-CAMKK2 Recombinant Antibody (239CT7.5.3) (CBMAB-C1269-CN)

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Target: CAMKK2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: 239CT7.5.3
Application*: WB
Datasheet SDS

Mouse Anti-CaMKK2 Recombinant Antibody (1A11) (CBMAB-C3509-LY)

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Target: CAMKK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 1A11
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-CAMKK2 Recombinant Antibody (EG471) (CBMAB-EN534-LY)

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Target: CAMKK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: EG471
Application*: WB, IP, IF, E
Datasheet SDS

CAMKK2 Matched Antibody Pair (178) (APMAB-178LY)

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Target: CAMKK2
Specificity: Human
Datasheet SDS

CAMKK2 Matched Antibody Pair (177) (APMAB-177LY)

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Target: CAMKK2
Specificity: Human
Datasheet SDS

Mouse Anti-CAMKK2 Recombinant Antibody (CBFYC-0779) (CBMAB-C0834-FY)

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Target: CAMKK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: CBFYC-0779
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-CAMKK2 Recombinant Antibody (3H6) (CBMAB-0184-YC)

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Target: CAMKK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H6
Application*: WB
Datasheet SDS

Mouse Anti-CAMKK2 Recombinant Antibody (4C7) (CBMAB-0421-CN)

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Target: CAMKK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 4C7
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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