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CASP2

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Full Name
Caspase 2
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321).
Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321).
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Aging Source: Ensembl
Apoptotic process Source: GO_Central
Apoptotic signaling pathway Source: UniProtKB
Brain development Source: Ensembl
Cellular response to mechanical stimulus Source: UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
Ectopic germ cell programmed cell death Source: Ensembl
Execution phase of apoptosis Source: UniProtKB
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Luteolysis Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Neural retina development Source: Ensembl
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of apoptotic signaling pathway Source: Ensembl
Positive regulation of neuron apoptotic process Source: Ensembl
Protein processing Source: BHF-UCL
Regulation of apoptotic process Source: Reactome
Cellular Location
Cytosol; Mitochondrion; Nucleus; Cytoplasm; Membrane
PTM
The mature protease can process its own propeptide, but not that of other caspases.

Anti-CASP2 antibodies

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Target: CASP2
Host: Rat
Specificity: Dog, Human, Mouse, Rat
Clone: CBFYC-0832
Application*: E, F, IC, IH
Target: CASP2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBFYC-0831
Application*: WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0376
Application*: E, WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1928
Application*: WB, E
Target: CASP2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBFYC-0833
Application*: WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 550CT8.5.2
Application*: WB, E
Target: CASP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG484
Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000
Target: CASP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1287
Application*: IC
Target: CASP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-0073
Application*: IF, E, WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0836
Application*: E, IF, WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF061
Application*: ELISA, WB
Target: CASP2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Dog, Human, Mouse, Rat
Clone: CBFYC-0835
Application*: IP, WB
Target: CASP2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Dog, Human, Mouse, Rat
Clone: CBFYC-0834
Application*: C, F, IF
Target: CASP2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: 18E809.3
Application*: WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1C10
Application*: WB, E
Target: CASP2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Dog, Monkey, Mouse, Rat
Clone: 10C6
Application*: E, F, IC, IH
Target: CASP2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Dog, Monkey, Mouse, Rat
Clone: 11B4
Application*: E, F, IC, IH, IP, WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12K17
Application*: IH
Target: CASP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4F8
Application*: WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: 4H39
Application*: WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0037
Application*: WB, IF
Target: CASP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0962
Application*: WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYY-C0963
Application*: WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0965
Application*: WB, E
Target: CASP2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Dog, Human, Monkey, Mouse, Rat
Clone: CBYY-C0967
Application*: E, F, IC, IH
Target: CASP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0968
Application*: WB
Target: CASP2
Host: Rat
Antibody Isotype: IgM
Specificity: Human
Clone: SB123a
Application*: WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: P1C10AT
Application*: E, WB
Target: CASP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb041
Application*: WB, IH, IF
Target: CASP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP306
Application*: FC, ICC, IF, IHC, WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP307
Application*: ICC, IHC, IP, WB
Target: CASP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP308
Application*: FC, ICC, IF, IHC, WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 18E809
Application*: WB
Target: CASP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C11
Application*: E, IF, WB
Target: CASP2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Dog, Monkey, Mouse, Rat
Clone: 6D216
Application*: E, F, IC, IH
Target: CASP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2992
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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