CASP2

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Full Name
Caspase 2
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321).
Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321).
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Aging Source: Ensembl
Apoptotic process Source: GO_Central
Apoptotic signaling pathway Source: UniProtKB
Brain development Source: Ensembl
Cellular response to mechanical stimulus Source: UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
Ectopic germ cell programmed cell death Source: Ensembl
Execution phase of apoptosis Source: UniProtKB
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Luteolysis Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Neural retina development Source: Ensembl
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of apoptotic signaling pathway Source: Ensembl
Positive regulation of neuron apoptotic process Source: Ensembl
Protein processing Source: BHF-UCL
Regulation of apoptotic process Source: Reactome
Cellular Location
Cytosol; Mitochondrion; Nucleus; Cytoplasm; Membrane
PTM
The mature protease can process its own propeptide, but not that of other caspases.
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Anti-CASP2 antibodies

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Rabbit Anti-CASP2 Recombinant Antibody (CAP308) (CBMAB-AP786LY)

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Target: CASP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CAP308
Application*: E, WB, IH
Datasheet SDS

Rabbit Anti-CASP2 Recombinant Antibody (CAP306) (CBMAB-AP783LY)

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Target: CASP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CAP306
Application*: E, WB
Datasheet SDS

Mouse Anti-CASP2 Recombinant Antibody (CBFYC-0836) (CBMAB-C0891-FY)

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Target: CASP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0836
Application*: IF
Datasheet SDS

Mouse Anti-CASP2 Recombinant Antibody (CBFYC-0833) (CBMAB-C0888-FY)

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Target: CASP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0833
Application*: E, IF, WB
Datasheet SDS

Rat Anti-CASP2 Recombinant Antibody (CBFYC-0832) (CBMAB-C0887-FY)

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Target: CASP2
Host: Rat
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBFYC-0832
Application*: WB
Datasheet SDS

Mouse Anti-CASP2 Recombinant Antibody (CBFYC-0831) (CBMAB-C0886-FY)

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Target: CASP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0831
Application*: E, IF, WB, IP
Datasheet SDS

Mouse Anti-CASP2 Recombinant Antibody (CBFYC-0376) (CBMAB-C0416-FY)

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Target: CASP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0376
Application*: E, IF, WB, IP
Datasheet SDS

Mouse Anti-CASP2 Recombinant Antibody (1C11) (CBMAB-C3706-LY)

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Target: CASP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C11
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-CASP2 Recombinant Antibody (1C10) (CBMAB-C0484-LY)

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Target: CASP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1C10
Application*: WB, IP
Datasheet SDS

Rabbit Anti-CASP2 Recombinant Antibody (
3D4) (V2LY-0725-LY1353)

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Target: CASP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 3D4
Application*: E, WB, IH
Datasheet SDS

Rabbit Anti-CASP2 Recombinant Antibody (
7E5) (V2LY-0725-LY1175)

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Target: CASP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 7E5
Application*: E, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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