CCN2

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.

Full Name

Cellular communication network factor 2

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Biological Process

Aging Source: Ensembl
Angiogenesis Source: Ensembl
Cartilage condensation Source: Ensembl
Cell adhesion Source: GO_Central
Cell differentiation Source: Ensembl
Cell-matrix adhesion Source: Ensembl
Cell migration Source: Ensembl
Chondrocyte proliferation Source: Ensembl
Cytosolic calcium ion transport Source: Ensembl
DNA biosynthetic process Source: UniProtKB-KW
Epidermis development Source: ProtInc
Extracellular matrix constituent secretion Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: Ensembl
Integrin-mediated signaling pathway Source: Ensembl
Intracellular signal transduction Source: Ensembl
Lung development Source: Ensembl
Negative regulation of cell death Source: GO_Central
Negative regulation of gene expression Source: Ensembl
Ossification Source: Ensembl
Positive regulation of cardiac muscle contraction Source: Ensembl
Positive regulation of cell activation Source: Ensembl
Positive regulation of cell death Source: Ensembl
Positive regulation of cell differentiation Source: BHF-UCL
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of collagen biosynthetic process Source: Ensembl
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of G0 to G1 transition Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of JNK cascade Source: BHF-UCL
Positive regulation of protein phosphorylation Source: Ensembl
Positive regulation of stress fiber assembly Source: BHF-UCL
Reactive oxygen species metabolic process Source: Ensembl
Regulation of chondrocyte differentiation Source: Ensembl
Response to amino acid Source: Ensembl
Response to anoxia Source: Ensembl
Response to estradiol Source: Ensembl
Response to fatty acid Source: Ensembl
Response to glucose Source: Ensembl
Response to mineralocorticoid Source: Ensembl
Response to peptide hormone Source: Ensembl
Response to wounding Source: ProtInc
Signal transduction Source: GO_Central
Tissue homeostasis Source: Ensembl
Transcription initiation from RNA polymerase II promoter Source: Reactome

Cellular Location

Extracellular matrix; Secreted