CD177

CD177 (CD177 Molecule) is a Protein Coding gene. Diseases associated with CD177 include Polycythemia and Polycythemia Vera. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. An important paralog of this gene is TEX101.
Full Name
CD177 Molecule
Function
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407).
In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980).
Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308).
However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681).
Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208).
By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369).
Biological Process
Blood coagulation Source: Reactome
Cell adhesion Source: UniProtKB
Cell-cell adhesion via plasma-membrane adhesion molecules Source: UniProtKB
Cell-cell junction maintenance Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Leukocyte cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Neutrophil degranulation Source: Reactome
Neutrophil extravasation Source: UniProtKB
Neutrophil migration Source: UniProtKB
Positive regulation of neutrophil degranulation Source: UniProtKB
Positive regulation of superoxide anion generation Source: UniProtKB
Protein localization to cell surface Source: UniProtKB
Regulation of endocytosis Source: UniProtKB
Regulation of integrin-mediated signaling pathway Source: UniProtKB
Cellular Location
Cell membrane; Secreted; Membrane raft; Cytoplasmic granule membrane; Lamellipodium. Cell surface expression on neutrophils is increased upon TNF-alpha, fMLP or CXCL8/IL8-mediated stimulation (PubMed:17244676, PubMed:17580308). In neutrophils, stored predominantly in secondary and tertiary granules (PubMed:18462208). Can also be shedded from the cell membrane (PubMed:12239154, PubMed:18462208). Localizes to lamellar protrusions in spreading neutrophils (PubMed:28807980).
PTM
N-glycosylated.
A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding).
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Anti-CD177 antibodies

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Mouse Anti-CD177 Recombinant Antibody (CBT2208) (V2LY-0625-LY1156)

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Target: CD177
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2208
Application*: WB, F
Datasheet SDS

Mouse Anti-CD177 Recombinant Antibody (CBT3380) (V2LY-0625-LY1154)

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Target: CD177
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3380
Application*: F
Datasheet SDS

CD177 Matched Antibody Pair (206) (APMAB-206LY)

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Target: CD177
Specificity: Human
Datasheet SDS

Mouse Anti-CD177 Recombinant Antibody (MEM-166) (CBMAB-C2200-CQ)

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Target: CD177
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: MEM-166
Application*: F, WB, IP
Datasheet SDS

Human Anti-CD177 Recombinant Antibody (CBYY-C3178) (CBMAB-C4621-YY)

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Target: CD177
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYY-C3178
Application*: F, IF, IH
Datasheet SDS

Mouse Anti-CD177 Recombinant Antibody (CBYY-C0298) (CBMAB-C1002-YY)

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Target: CD177
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C0298
Application*: E, IF, IP, WB, P
Datasheet SDS

Mouse Anti-CD177 Recombinant Antibody (CBYY-C0159) (CBMAB-C0507-YY)

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Target: CD177
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C0159
Application*: E, IF, IP, WB, P
Datasheet SDS

Mouse Anti-CD177 Recombinant Antibody (4C4) (CBMAB-C6729-LY)

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Target: CD177
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4C4
Application*: E, IP, IH, WB
Datasheet SDS

Mouse Anti-CD177 Recombinant Antibody (08) (CBMAB-C1861-LY)

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Target: CD177
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 08
Application*: E
Datasheet SDS

Rabbit Anti-CD177 Recombinant Antibody (021) (CBMAB-C1675-LY)

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Target: CD177
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 021
Application*: E
Datasheet SDS

Mouse Anti-CD177 Recombinant Antibody (05) (CBMAB-C0078-LY)

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Target: CD177
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 05
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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