CDC16 (Phospho-Ser560)

CDC16 (Cell Division Cycle 16) is a Protein Coding gene. Among its related pathways are PAK Pathway and Actin Nucleation by ARP-WASP Complex.

Full Name

Cell Division Cycle 16

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Biological Process

Anaphase-promoting complex-dependent catabolic process Source: GO_Central
Cell division Source: GO_Central
Metaphase/anaphase transition of mitotic cell cycle Source: GO_Central
Positive regulation of mitotic metaphase/anaphase transition Source: GO_Central
Protein K11-linked ubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of exit from mitosis Source: Reactome
Regulation of mitotic cell cycle phase transition Source: Reactome
Ubiquitin-dependent protein catabolic process Source: Reactome

Cellular Location

Centrosome; Spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.

PTM

Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.