CSK

CSK (C-Terminal Src Kinase) is a Protein Coding gene. Diseases associated with CSK include Osteopetrosis and Breast Cancer. Among its related pathways are RET signaling and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is MATK.

Full Name

C-Terminal Src Kinase

Function

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Adherens junction organization Source: GO_Central
Brain development Source: Ensembl
Cellular response to peptide hormone stimulus Source: Ensembl
Cytokine-mediated signaling pathway Source: Reactome
Negative regulation of bone resorption Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of Golgi to plasma membrane protein transport Source: UniProtKB
Negative regulation of interleukin-6 production Source: Ensembl
Negative regulation of kinase activity Source: Ensembl
Negative regulation of low-density lipoprotein particle clearance Source: Ensembl
Negative regulation of phagocytosis Source: Ensembl
Oligodendrocyte differentiation Source: Ensembl
Positive regulation of MAP kinase activity Source: Ensembl
Protein autophosphorylation Source: Ensembl
Protein phosphorylation Source: ProtInc
Regulation of Fc receptor mediated stimulatory signaling pathway Source: GO_Central
T cell costimulation Source: Reactome
T cell receptor signaling pathway Source: Reactome

Cellular Location

Cell membrane; Cytoplasm. Mainly cytoplasmic, also present in lipid rafts.

PTM

Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.