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CSPG4

CSPG4P1Y (Chondroitin Sulfate Proteoglycan 4 Pseudogene 1, Y-Linked) is a Pseudogene.
Full Name
Chondroitin Sulfate Proteoglycan 4
Function
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
Biological Process
Activation of MAPK activity Source: Ensembl
Angiogenesis Source: UniProtKB-KW
Cell population proliferation Source: Ensembl
Chondroitin sulfate biosynthetic process Source: Reactome
Chondroitin sulfate catabolic process Source: Reactome
Dermatan sulfate biosynthetic process Source: Reactome
Glial cell migration Source: Ensembl
Intracellular signal transduction Source: UniProtKB
Platelet-derived growth factor receptor signaling pathway Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Ruffle assembly Source: Ensembl
Substrate-dependent cell migration Source: Ensembl
Tissue remodeling Source: UniProtKB-KW
Cellular Location
Cell membrane; Apical cell membrane; Lamellipodium membrane; Cell surface. Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity).
Topology
Extracellular: 30-2224
Helical: 2225-2245
Cytoplasmic: 2246-2322
PTM
O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4.
Phosphorylation by PRKCA regulates its subcellular location and function in cell motility.
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Anti-CSPG4 antibodies

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Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1050) (CBMAB-M1203-FY)

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Target: CSPG4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: CBFYM-1050
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-CSPG4 Recombinant Antibody (CBT3422) (V2LY-0625-LY9)

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Target: CSPG4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3422
Application*: F
Datasheet SDS

Rabbit Anti-CSPG4 Recombinant Antibody (CBFYM-1054) (V2LY-0125-LY74)

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Target: CSPG4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYM-1054
Application*: WB, P, F
Datasheet SDS

Rabbit Anti-CSPG4 Recombinant Antibody (CBFYM-1053) (V2LY-0125-LY73)

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Target: CSPG4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-1053
Application*: E, WB
Datasheet SDS

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1051) (V2LY-0125-LY71)

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Target: CSPG4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1051
Application*: IP, IF, F
Datasheet SDS

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1047) (V2LY-0125-LY67)

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Target: CSPG4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1047
Application*: WB, IP, IF, E
Datasheet SDS

Human Anti-CSPG4 Recombinant Antibody (CBFYM-0005) (V2LY-0125-LY66)

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Target: CSPG4
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0005
Application*: F
Datasheet SDS

Mouse Anti-CSPG4 Recombinant Antibody (CBWJN-0588) (V2LY-0125-LY65)

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Target: CSPG4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0588
Application*: WB, IP, IF, F
Datasheet SDS

Mouse Anti-CSPG4 Recombinant Antibody (CBWJN-0900) (V2LY-0125-LY61)

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Target: CSPG4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0900
Application*: F, IP, WB, IH
Datasheet SDS

Rat Anti-CSPG4 Recombinant Monoclonal Antibody (1420) (V2LY-0125-LY60)

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Target: CSPG4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 1420
Application*: IF, IH
Datasheet SDS

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1055) (CBMAB-M1208-FY)

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Target: CSPG4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYM-1055
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1052) (CBMAB-M1205-FY)

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Target: CSPG4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1052
Application*: F, P
Datasheet SDS

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1049) (CBMAB-M1202-FY)

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Target: CSPG4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: CBFYM-1049
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1048) (CBMAB-M1201-FY)

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Target: CSPG4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYM-1048
Application*: WB, IP, IF, E
Datasheet SDS

Rat Anti-CSPG4 Recombinant Antibody (CBWJN-1076) (CBMAB-N0689-WJ)

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Target: CSPG4
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBWJN-1076
Application*: IH, IF, F
Datasheet SDS

Mouse Anti-CSPG4 Recombinant Antibody (N0021) (CBMAB-N0021-WJ)

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Target: CSPG4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: N0021
Application*: WB, F, P, IF, IP
Datasheet SDS

Mouse Anti-CSPG4 Recombinant Antibody (CBWJN-0499) (CBMAB-N0020-WJ)

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Target: CSPG4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJN-0499
Application*: E, WB, F
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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