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CSPG4

CSPG4P1Y (Chondroitin Sulfate Proteoglycan 4 Pseudogene 1, Y-Linked) is a Pseudogene.

Full Name

Chondroitin Sulfate Proteoglycan 4

Function

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

Biological Process

Activation of MAPK activity Source: Ensembl
Angiogenesis Source: UniProtKB-KW
Cell population proliferation Source: Ensembl
Chondroitin sulfate biosynthetic process Source: Reactome
Chondroitin sulfate catabolic process Source: Reactome
Dermatan sulfate biosynthetic process Source: Reactome
Glial cell migration Source: Ensembl
Intracellular signal transduction Source: UniProtKB
Platelet-derived growth factor receptor signaling pathway Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Ruffle assembly Source: Ensembl
Substrate-dependent cell migration Source: Ensembl
Tissue remodeling Source: UniProtKB-KW

Cellular Location

Cell membrane; Apical cell membrane; Lamellipodium membrane; Cell surface. Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity).

Topology

Extracellular: 30-2224
Helical: 2225-2245
Cytoplasmic: 2246-2322

PTM

O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4.
Phosphorylation by PRKCA regulates its subcellular location and function in cell motility.

Anti-CSPG4 antibodies

Mouse Anti-CSPG4 Recombinant Antibody (ME313) (CBMAB-1459-CN)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: ME313

Application*: WB

Mouse Anti-CSPG4 Recombinant Antibody (7G4E5) (CBMAB-1458-CN)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 7G4E5

Application*: WB, E, F

Mouse Anti-CSPG4 Recombinant Antibody (CBCNC-410) (CBMAB-C2965-CN)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgM

Specificity: Cat

Clone: CBCNC-410

Application*: ICC, C, IP, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBCNC-088) (CBMAB-C0982-CN)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cat

Clone: CBCNC-088

Application*: ICC, IH, IP, WB

Rat Anti-CSPG4 Monoclonal Antibody (546930) (CBMAB-1420-YC)

SDS

Target: CSPG4

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 546930

Application*: C

Mouse Anti-CSPG4 Monoclonal Antibody (132.38) (CBMAB-1419-YC)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: 132.38

Application*: E, IC, IF, C, IP, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBYY-C2194) (CBMAB-C3632-YY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Rat

Clone: CBYY-C2194

Application*: E, IF, IH, IP, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBYY-C2193) (CBMAB-C3631-YY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBYY-C2193

Application*: IH, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBYY-C0720) (CBMAB-C2127-YY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-C0720

Application*: F, IF, IP

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1058) (CBMAB-M1211-FY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Rat

Clone: CBFYM-1058

Application*: E, IF, C, IP, WB

Mouse Anti-CSPG4 (AA 1592-2222) Recombinant Antibody (CBFYM-1056) (CBMAB-M1209-FY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBFYM-1056

Application*: IH, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1055) (CBMAB-M1208-FY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBFYM-1055

Application*: E, IH, IP

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1054) (CBMAB-M1207-FY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYM-1054

Application*: WB, IC, C, P, E

Mouse Anti-CSPG4 (AA 559-776) Recombinant Antibody (CBFYM-1053) (CBMAB-M1206-FY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYM-1053

Application*: E

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1052) (CBMAB-M1205-FY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-1052

Application*: WB

Mouse Anti-CSPG4 Recombinant Antibody (CBWJN-0900) (CBMAB-N0019-WJ)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0900

Application*: F, IP, MC

Mouse Anti-CSPG4 Recombinant Antibody (CBWJN-0499) (CBMAB-N0020-WJ)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBWJN-0499

Application*: F, IC, IF, P, IP

Mouse Anti-CSPG4 Recombinant Antibody (LHM 2) (CBMAB-N0021-WJ)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: LHM 2

Application*: WB, F, IH, IF, IP, P, C

Rat Anti-CSPG4 Recombinant Antibody (CBWJN-1076) (CBMAB-N0689-WJ)

SDS

Target: CSPG4

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBWJN-1076

Application*: IH

Mouse Anti-CSPG4 Recombinant Antibody (CBWJN-0588) (CBMAB-N0692-WJ)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Rat

Clone: CBWJN-0588

Application*: E, IF, C, IP

Mouse Anti-CSPG4 Recombinant Antibody (N143.8) (CBMAB-N0694-WJ)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Rat

Clone: N143.8

Application*: E, IF, C, IP, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-0005) (CBMAB-M0006-FY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0005

Application*: F

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1047) (CBMAB-M1200-FY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgM

Specificity: Cat

Clone: CBFYM-1047

Application*: IC, C, IP, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1048) (CBMAB-M1201-FY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-1048

Application*: F, FN, IF, IP

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1049) (CBMAB-M1202-FY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-1049

Application*: F, IC, IF, IH, IP, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1050) (CBMAB-M1203-FY)

SDS

Target: CSPG4

Host: Mouse

Specificity: Human

Clone: CBFYM-1050

Application*: E, WB, IH

Mouse Anti-CSPG4 Recombinant Antibody (CBFYM-1051) (CBMAB-M1204-FY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-1051

Application*: F, C, P, IP, WB

Mouse Anti-CSPG4 Recombinant Antibody (6) (CBMAB-C7841-LY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6

Application*: WB, IC, P, C, E, IP, IF, F

Mouse Anti-CSPG4 Recombinant Antibody (9.9.27) (CBMAB-C9303-LY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 9.9.27

Application*: F, IF, IP

Mouse Anti-CSPG4 Recombinant Antibody (CBYY-C2195) (CBMAB-C3633-YY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-C2195

Application*: WB, IC, P, C, E, IP, IF, F

Mouse Anti-CSPG4 (AA 2247-2308) Recombinant Antibody (CBYY-C2196) (CBMAB-C3634-YY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C2196

Application*: E, F, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBYY-C2197) (CBMAB-C3635-YY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-C2197

Application*: F, IF, IP

Mouse Anti-CSPG4 Recombinant Antibody (14i127) (CBMAB-C2964-CN)

SDS

Target: CSPG4

Host: Mouse

Specificity: Human

Clone: 14i127

Application*: E, FC, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBCNC-411) (CBMAB-C2966-CN)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNC-411

Application*: ICC, C, IP, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBCNC-412) (CBMAB-C2967-CN)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBCNC-412

Application*: FC, IF, IP

Mouse Anti-CSPG4 Recombinant Antibody (CBCNC-414) (CBMAB-C2969-CN)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBCNC-414

Application*: E, ICC, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBCNC-415) (CBMAB-C2970-CN)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBCNC-415

Application*: IH, WB

Mouse Anti-CSPG4 Recombinant Antibody (CBLC190-LY) (CBMAB-C11248-LY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Rat

Clone: CBLC190-LY

Application*: F

Mouse Anti-CSPG4 Recombinant Antibody (3H395) (CBMAB-C11249-LY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: 3H395

Application*: E, IC, IH, WB

Mouse Anti-CSPG4 Recombinant Antibody (A109) (CBMAB-AP4450LY)

SDS

Target: CSPG4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: A109

Application*: ICC, IHC, IP, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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