EIF5A

EIF5A (Eukaryotic Translation Initiation Factor 5A) is a Protein Coding gene. Diseases associated with EIF5A include Human Immunodeficiency Virus Type 1 and Retinitis Pigmentosa 14. Among its related pathways are Metabolism of proteins and Translation Factors. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding. An important paralog of this gene is EIF5AL1.
Full Name
Eukaryotic Translation Initiation Factor 5A
Research Area
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
Biological Process
Cellular response to virus Source: UniProtKB
mRNA transport Source: UniProtKB-KW
Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of translational elongation Source: UniProtKB
Positive regulation of translational termination Source: InterPro
Protein transport Source: UniProtKB-KW
Tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane; Nucleus; Nuclear pore complex; Cytoplasm. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
PTM
Acetylated. Deacetylated by SIRT2.
eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
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Anti-EIF5A antibodies

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Rabbit Anti-EIF5A Recombinant Antibody (
5E1) (V2LY-0725-LY1491)

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Target: EIF5A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 5E1
Application*: E, WB, IH, IF, F
Datasheet SDS

Mouse Anti-EIF5A Recombinant Antibody (CBT4744) (V2LY-0625-LY261)

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Target: EIF5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4744
Application*: IH, F
Datasheet SDS

Mouse Anti-EIF5A Recombinant Antibody (CBT3105) (V2LY-0625-LY193)

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Target: EIF5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3105
Application*: IH, IC, F
Datasheet SDS

Rabbit Anti-EIF5A Recombinant Antibody (0573) (CBMAB-CP0573-LY)

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Target: EIF5A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 0573
Application*: WB, P
Datasheet SDS

Mouse Anti-EIF5A Recombinant Antibody (8C1) (CBMAB-A2553-LY)

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Target: EIF5A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 8C1
Application*: WB, E, IF
Datasheet SDS

Mouse Anti-EIF5A Recombinant Antibody (CBFYE-0748) (CBMAB-E1186-FY)

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Target: EIF5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYE-0748
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-EIF5A Recombinant Antibody (CBFYE-0747) (CBMAB-E1184-FY)

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Target: EIF5A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBFYE-0747
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-EIF5A Recombinant Antibody (CBFYE-0191) (CBMAB-E0434-FY)

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Target: EIF5A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Clone: CBFYE-0191
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-EIF5A Recombinant Antibody (CBFYE-0079) (CBMAB-E0170-FY)

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Target: EIF5A
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Clone: CBFYE-0079
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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