FAT1

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]

Full Name

FAT Atypical Cadherin 1

Research Area

Protocadherin Fat 1:
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.

Biological Process

Actin filament organization Source: UniProtKB
Anatomical structure morphogenesis Source: ProtInc
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cell migration Source: UniProtKB
Epithelial cell morphogenesis Source: Ensembl
Establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis Source: Ensembl
Establishment or maintenance of cell polarity Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Lens development in camera-type eye Source: Ensembl

Cellular Location

Protocadherin Fat 1: Cell membrane
Protocadherin Fat 1, nuclear form: Nucleus

Topology

Extracellular: 22-4181
Helical: 4182-4202
Cytoplasmic: 4203-4588

PTM

Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus.