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FAT1

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
Full Name
FAT Atypical Cadherin 1
Research Area
Protocadherin Fat 1:
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
Biological Process
Actin filament organization Source: UniProtKB
Anatomical structure morphogenesis Source: ProtInc
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cell migration Source: UniProtKB
Epithelial cell morphogenesis Source: Ensembl
Establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis Source: Ensembl
Establishment or maintenance of cell polarity Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Lens development in camera-type eye Source: Ensembl
Cellular Location
Protocadherin Fat 1: Cell membrane
Protocadherin Fat 1, nuclear form: Nucleus
Topology
Extracellular: 22-4181
Helical: 4182-4202
Cytoplasmic: 4203-4588
PTM
Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus.

Anti-FAT1 antibodies

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Target: FAT1
Host: Mouse
Antibody Isotype: IgM
Specificity: Fruit fly
Clone: 3D7/1
Application*: WB, E, IH, IF
Target: FAT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3472
Application*: E, WB
Target: FAT1
Host: Mouse
Antibody Isotype: IgM
Specificity: Fruit fly
Clone: Fat-1
Application*: WB, E, IF
Target: FAT1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2871
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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