FBLIM1

This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
Full Name
filamin binding LIM protein 1
Research Area
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.
Biological Process
Cell-cell adhesion Source: UniProtKB
Regulation of cell shape Source: UniProtKB-KW
Regulation of integrin activation Source: UniProtKB
Cellular Location
Stress fiber; Focal adhesion. Associated with actin stress fiber at cell-ECM focal adhesion sites (PubMed:12679033, PubMed:18829455). Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2 (PubMed:12679033). Isoform 2 is localized at actin stress fibers (PubMed:12496242).
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Anti-FBLIM1 antibodies

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Mouse Anti-FBLIM1 Recombinant Antibody (3F8) (CBMAB-A2861-LY)

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Target: FBLIM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F8
Application*: WB, E
Datasheet SDS

Mouse Anti-FBLIM1 Recombinant Antibody (5E11) (CBMAB-A2860-LY)

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Target: FBLIM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5E11
Application*: WB, E
Datasheet SDS

Mouse Anti-FBLIM1 (AA 1-242 ) Recombinant Antibody (CBFYM-1088) (CBMAB-M1243-FY)

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Target: FBLIM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1088
Application*: WB
Datasheet SDS

Mouse Anti-FBLIM1 Recombinant Antibody (CBXF-1465) (CBMAB-F4030-CQ)

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Target: FBLIM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-1465
Application*: WB
Datasheet SDS

Mouse Anti-FBLIM1 (AA 270-373) Recombinant Antibody (CBXF-2881) (CBMAB-F3589-CQ)

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Target: FBLIM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2881
Application*: E, WB
Datasheet SDS

Mouse Anti-FBLIM1 Recombinant Antibody (CBXF-2880) (CBMAB-F3588-CQ)

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Target: FBLIM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-2880
Application*: E, WB
Datasheet SDS

Mouse Anti-FBLIM1 (AA 1-242) Recombinant Antibody (3G1) (CBMAB-F2274-CQ)

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Target: FBLIM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G1
Application*: WB
Datasheet SDS

Mouse Anti-FBLIM1 Recombinant Antibody (CBXF-0357) (CBMAB-F2222-CQ)

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Target: FBLIM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0357
Application*: WB
Datasheet SDS

Mouse Anti-FBLIM1 Recombinant Antibody (CBXF-0358) (CBMAB-F0342-CQ)

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Target: FBLIM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0358
Application*: WB
Datasheet SDS

Mouse Anti-FBLIM1 (AA 270-374) Recombinant Antibody (CBXF-0356) (CBMAB-F0279-CQ)

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Target: FBLIM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-0356
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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