FBXO8

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq]
Full Name
F-box protein 8
Research Area
May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).
Biological Process
Regulation of ARF protein signal transduction Source: InterPro
Ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Ubiquitin ligase complex
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Anti-FBXO8 antibodies

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Mouse Anti-FBXO8 Recombinant Antibody (1C11) (V2LY-0925-LY501)

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Target: FBXO8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C11
Application*: WB, E
Datasheet SDS

Mouse Anti-FBXO8 Recombinant Antibody (CBXF-2910) (V2LY-0925-LY500)

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Target: FBXO8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-2910
Application*: E, WB
Datasheet SDS

Mouse Anti-FBXO8 Recombinant Antibody (CBXF-3563) (V2LY-0925-LY495)

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Target: FBXO8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBXF-3563
Application*: WB
Datasheet SDS

Mouse Anti-FBXO8 Recombinant Antibody (CBXF-3685) (V2LY-0925-LY494)

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Target: FBXO8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBXF-3685
Application*: WB, IH
Datasheet SDS

Mouse Anti-FBXO8 Recombinant Antibody (CBXF-2500) (V2LY-0925-LY493)

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Target: FBXO8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXF-2500
Application*: WB, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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