FBXO8
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq]
Full Name
F-box protein 8
Research Area
May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).
Biological Process
Regulation of ARF protein signal transduction Source: InterPro
Ubiquitin-dependent protein catabolic process Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Ubiquitin ligase complex
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Anti-FBXO8 antibodies
+ Filters

Target: FBXO8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C11
Application*: WB, E
Target: FBXO8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2910
Application*: E, WB
Target: FBXO8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0420
Application*: SE, E, WB
Target: FBXO8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3772
Application*: WB
Target: FBXO8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C5
Application*: WB, IH
Target: FBXO8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3E8
Application*: WB
Target: FBXO8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-3563
Application*: WB
Target: FBXO8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3685
Application*: WB, E
Target: FBXO8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2500
Application*: WB, IH
Target: FBXO8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0421
Application*: E, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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