FETUB
The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells.
Full Name
Fetuin B
Research Area
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).
Biological Process
Binding of sperm to zona pellucida Source: UniProtKB
Negative regulation of endopeptidase activity Source: UniProtKB
Single fertilization Source: UniProtKB
Negative regulation of endopeptidase activity Source: UniProtKB
Single fertilization Source: UniProtKB
Cellular Location
Secreted
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Anti-FETUB antibodies
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Target: FETUB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0508
Application*: E, WB
Target: FETUB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-3507
Application*: E
Target: FETUB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-3505
Application*: E
Target: FETUB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1138
Application*: E
Target: FETUB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0507
Application*: WB
Target: FETUB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2604
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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