FGF13

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini.

Full Name

Fibroblast Growth Factor 13

Research Area

Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity).

Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity).

Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity).

May regulate voltage-gated sodium channels transport and function (PubMed:15282281).

May also play a role in MAPK signaling (By similarity).

Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity).

Biological Process

Cell-cell signaling Source: ProtInc
Cerebral cortex cell migration Source: UniProtKB
Establishment of neuroblast polarity Source: UniProtKB
Hippocampus development Source: UniProtKB
Inhibitory synapse assembly Source: UniProtKB
Learning Source: UniProtKB
MAPK cascade Source: MGI
Memory Source: UniProtKB
Microtubule polymerization Source: UniProtKB
Negative regulation of collateral sprouting Source: UniProtKB
Negative regulation of microtubule depolymerization Source: UniProtKB
Nervous system development Source: ProtInc
Neuron migration Source: UniProtKB
Protein localization to plasma membrane Source: UniProtKB
Regulation of cardiac muscle cell action potential involved in regulation of contraction Source: BHF-UCL
Regulation of voltage-gated sodium channel activity Source: GO_Central
Response to odorant Source: Ensembl
Signal transduction Source: ProtInc
Sodium ion transport Source: BHF-UCL

Cellular Location

Nucleus; Cytoplasm; Filopodium; Growth cone; Dendrite. Not secreted.
Isoform 1: Nucleolus
Isoform 2: Nucleus; Cytoplasm

PTM

May be phosphorylated.