FN3K

A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012]
Full Name
Fructosamine 3 Kinase
Function
Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663).

Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663).

Involved in intracellular deglycation in erythrocytes (PubMed:11975663).

Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity).

Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848).
Biological Process
Epithelial cell differentiation Source: UniProtKB
Fructosamine metabolic process Source: GO_Central
Fructoselysine metabolic process Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein deglycation Source: UniProtKB
Cellular Location
Cytosol
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Anti-FN3K antibodies

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Mouse Anti-FN3K Recombinant Antibody (4F2) (CBMAB-A3059-LY)

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Target: FN3K
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F2
Application*: WB, E
Datasheet SDS

Mouse Anti-FN3K Recombinant Antibody (CBXF-3108) (CBMAB-F3804-CQ)

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Target: FN3K
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3108
Application*: WB
Datasheet SDS

Mouse Anti-FN3K Recombinant Antibody (CAP781) (CBMAB-AP2357LY)

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Target: FN3K
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP781
Application*: WB
Datasheet SDS

Mouse Anti-FN3K Recombinant Antibody (CBXF-3107) (CBMAB-F3803-CQ)

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Target: FN3K
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-3107
Application*: E, WB
Datasheet SDS

Mouse Anti-FN3K Recombinant Antibody (CBXF-3468) (CBMAB-F2532-CQ)

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Target: FN3K
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3468
Application*: WB
Datasheet SDS

Mouse Anti-FN3K (AA 61-171) Recombinant Antibody (CBXF-0797) (CBMAB-F0448-CQ)

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Target: FN3K
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0797
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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