FNBP1L

The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Full Name

formin binding protein 1-like

Function

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.

Biological Process

Autophagy Source: UniProtKB-KW
Cilium assembly Source: MGI
Clathrin-dependent endocytosis Source: BHF-UCL
Membrane invagination Source: BHF-UCL
Plasma membrane tubulation Source: BHF-UCL
Positive regulation of filopodium assembly Source: BHF-UCL
Signal transduction Source: InterPro
Vesicle budding from membrane Source: BHF-UCL
Vesicle organization Source: BHF-UCL
Vesicle transport along actin filament Source: BHF-UCL

Cellular Location

Cytoskeleton; Cytoplasm; Cell membrane; Cell cortex; Cytoplasmic vesicle