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Mouse Anti-FNBP1L (AA 175-239) Recombinant Antibody (CBXF-3109) (CBMAB-F3805-CQ)

This product is a mouse antibody that recognizes FNBP1L (AA 175-239). The antibody CBXF-3109 can be used for immunoassay techniques such as: ELISA, WB.
See all FNBP1L antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-3109
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
FNBP1L (NP_060207.2, 175aa-239aa) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 175-239

Target

Full Name
formin binding protein 1-like
Introduction
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
54874
UniProt ID
Q5T0N5
Alternative Names
Formin Binding Protein 1 Like; Transducer Of Cdc42-Dependent Actin Assembly Protein 1; C1orf39; Toca-1; TOCA1; Transducer Of Cdc42-Dependent Actin Assembly 1; Chromosome 1 Open Reading Frame 39; Formin Binding Protein 1-Like; Formin-Binding Protein 1-Like;
Function
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.
Biological Process
Autophagy Source: UniProtKB-KW
Cilium assembly Source: MGI
Clathrin-dependent endocytosis Source: BHF-UCL
Membrane invagination Source: BHF-UCL
Plasma membrane tubulation Source: BHF-UCL
Positive regulation of filopodium assembly Source: BHF-UCL
Signal transduction Source: InterPro
Vesicle budding from membrane Source: BHF-UCL
Vesicle organization Source: BHF-UCL
Vesicle transport along actin filament Source: BHF-UCL
Cellular Location
Cytoskeleton; Cytoplasm; Cell membrane; Cell cortex; Cytoplasmic vesicle
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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