Mouse Anti-FNBP1L (AA 175-239) Recombinant Antibody (CBXF-3109) (CBMAB-F3805-CQ)

Name: Mouse Anti-FNBP1L (AA 175-239) Recombinant Antibody (CBXF-3109)
SKU: CBMAB-F3805-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXF-3109

Application

ELISA, WB

Immunogen

FNBP1L (NP_060207.2, 175aa-239aa) partial recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 175-239

More Infomation

Target

Full Name

formin binding protein 1-like

Introduction

The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.

Entrez Gene ID

54874

UniProt ID

Q5T0N5

Alternative Names

Formin Binding Protein 1 Like; Transducer Of Cdc42-Dependent Actin Assembly Protein 1; C1orf39; Toca-1; TOCA1; Transducer Of Cdc42-Dependent Actin Assembly 1; Chromosome 1 Open Reading Frame 39; Formin Binding Protein 1-Like; Formin-Binding Protein 1-Like;

Function

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.

Biological Process

Autophagy Source: UniProtKB-KW
Cilium assembly Source: MGI
Clathrin-dependent endocytosis Source: BHF-UCL
Membrane invagination Source: BHF-UCL
Plasma membrane tubulation Source: BHF-UCL
Positive regulation of filopodium assembly Source: BHF-UCL
Signal transduction Source: InterPro
Vesicle budding from membrane Source: BHF-UCL
Vesicle organization Source: BHF-UCL
Vesicle transport along actin filament Source: BHF-UCL

Cellular Location

Cytoskeleton; Cytoplasm; Cell membrane; Cell cortex; Cytoplasmic vesicle

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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