Mouse Anti-FNBP1L Recombinant Antibody (1E6) (CBMAB-A3060-LY)

Name: Mouse Anti-FNBP1L Recombinant Antibody (1E6)
SKU: CBMAB-A3060-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1E6

Application

WB, ELISA

Immunogen

FNBP1L (NP_060207.2, 175 a.a. ~ 239 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

formin binding protein 1-like

Introduction

The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Entrez Gene ID

54874

UniProt ID

Q5T0N5

Alternative Names

C1orf39; TOCA1

Function

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.

Biological Process

Autophagy Source: UniProtKB-KW
Cilium assembly Source: MGI
Clathrin-dependent endocytosis Source: BHF-UCL
Membrane invagination Source: BHF-UCL
Plasma membrane tubulation Source: BHF-UCL
Positive regulation of filopodium assembly Source: BHF-UCL
Signal transduction Source: InterPro
Vesicle budding from membrane Source: BHF-UCL
Vesicle organization Source: BHF-UCL
Vesicle transport along actin filament Source: BHF-UCL

Cellular Location

Cytoskeleton; Cytoplasm; Cell membrane; Cell cortex; Cytoplasmic vesicle

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-FNBP1L (AA 175-239) Recombinant Antibody (CBXF-3109) (CAT#: CBMAB-F3805-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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